109730

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2266717..2266980 Replicon chromosome
Accession NZ_CP031670
Organism Staphylococcus aureus strain 64

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag DD547_RS11920 Protein ID WP_001802298.1
Coordinates 2266876..2266980 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 2266717..2266881 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DD547_RS11900 2262900..2263565 - 666 WP_001024094.1 SDR family oxidoreductase -
DD547_RS11905 2263717..2264037 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
DD547_RS11910 2264039..2265019 + 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
DD547_RS11915 2265285..2266376 + 1092 WP_000495671.1 lytic regulatory protein -
- 2266717..2266881 + 165 - - Antitoxin
DD547_RS11920 2266876..2266980 - 105 WP_001802298.1 hypothetical protein Toxin
DD547_RS15250 2267141..2267624 - 484 Protein_2208 recombinase family protein -
DD547_RS11930 2267667..2268803 - 1137 WP_000115562.1 SAP domain-containing protein -
DD547_RS11935 2269092..2269184 + 93 WP_001790138.1 hypothetical protein -
DD547_RS11940 2269889..2270746 - 858 WP_000370924.1 Cof-type HAD-IIB family hydrolase -
DD547_RS11945 2270814..2271596 - 783 WP_000908177.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-134)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T109730 WP_001802298.1 NZ_CP031670:c2266980-2266876 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T109730 NZ_CP031670:c2266980-2266876 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 165 bp

>AT109730 NZ_CP031670:2266717-2266881 [Staphylococcus aureus]
GTAGCAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References