Detailed information of TA system TA109725

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1967010..1967192
• Replicon: chromosome
• Accession: NZ_CP031670
• Organism: Staphylococcus aureus strain 64

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: DD547_RS10155
• Protein ID: WP_001801861.1
• Coordinates: 1967010..1967105 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1967133..1967192 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DD547_RS10105	1962670..1963296	+	627	WP_000669046.1	hypothetical protein	-
DD547_RS10110	1963337..1963681	+	345	WP_000627551.1	DUF3969 family protein	-
DD547_RS10115	1963779..1964330	+	552	WP_000414205.1	hypothetical protein	-
DD547_RS10120	1964548..1965189	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
DD547_RS10125	1965303..1965488	-	186	WP_000809857.1	hypothetical protein	-
DD547_RS10130	1965490..1965666	-	177	WP_000375476.1	hypothetical protein	-
DD547_RS10135	1965677..1966060	-	384	WP_000070812.1	hypothetical protein	-
DD547_RS10145	1966664..1966807	-	144	WP_001549059.1	transposase	-
DD547_RS10155	1967010..1967105	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1967133..1967192	-	60	-	-	Antitoxin
DD547_RS10160	1967228..1967329	+	102	WP_001791893.1	hypothetical protein	-
DD547_RS10165	1967307..1967483	-	177	Protein_1922	transposase	-
DD547_RS10170	1967677..1968054	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1940984..2018744	77760

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T109725 WP_001801861.1 NZ_CP031670:1967010-1967105 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T109725 NZ_CP031670:1967010-1967105 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT109725 NZ_CP031670:c1967192-1967133 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin