Detailed information of TA system TA109719

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 892947..893285
• Replicon: chromosome
• Accession: NZ_CP031670
• Organism: Staphylococcus aureus strain 64

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: DD547_RS04605
• Protein ID: WP_011447039.1
• Coordinates: 892947..893123 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	893111..893285 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DD547_RS04585	890777..890929	+	153	WP_001000058.1	hypothetical protein	-
DD547_RS04590	890975..891262	+	288	WP_001262621.1	hypothetical protein	-
DD547_RS04595	891318..891692	+	375	WP_000340977.1	hypothetical protein	-
DD547_RS04600	892065..892838	+	774	WP_000750412.1	staphylococcal enterotoxin type A	-
DD547_RS04605	892947..893123	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	893111..893285	-	175	-	-	Antitoxin
DD547_RS04615	893335..893589	+	255	WP_000611512.1	phage holin	-
DD547_RS04620	893601..894356	+	756	Protein_855	CHAP domain-containing protein	-
DD547_RS04625	894547..895038	+	492	WP_000920038.1	staphylokinase	-
DD547_RS04640	895689..896024	+	336	Protein_857	SH3 domain-containing protein	-
DD547_RS04645	896269..896421	+	153	WP_001788502.1	hypothetical protein	-
DD547_RS04650	896492..896602	+	111	WP_000139423.1	hypothetical protein	-
DD547_RS04655	896604..896789	+	186	WP_001286805.1	hypothetical protein	-
DD547_RS04660	897425..897982	+	558	WP_000528632.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sea / sak	852668..897982	45314

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T109719 WP_011447039.1 NZ_CP031670:892947-893123 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T109719 NZ_CP031670:892947-893123 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT109719 NZ_CP031670:c893285-893111 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin