Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2506171..2506355 Replicon chromosome
Accession NZ_CP031664
Organism Staphylococcus aureus strain 28

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag DD545_RS13200 Protein ID WP_000482650.1
Coordinates 2506248..2506355 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2506171..2506231 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DD545_RS13175 2501701..2501868 - 168 WP_117207278.1 hypothetical protein -
DD545_RS13185 2502099..2503832 - 1734 Protein_2440 ABC transporter ATP-binding protein -
DD545_RS13190 2503857..2505620 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 2506171..2506231 + 61 - - Antitoxin
DD545_RS13200 2506248..2506355 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
DD545_RS13205 2506489..2506875 - 387 WP_000779358.1 flippase GtxA -
DD545_RS13210 2507143..2508285 + 1143 WP_001176863.1 glycerate kinase -
DD545_RS13215 2508345..2509004 + 660 WP_000831298.1 membrane protein -
DD545_RS13220 2509186..2510397 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
DD545_RS13225 2510520..2510993 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T109697 WP_000482650.1 NZ_CP031664:c2506355-2506248 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T109697 NZ_CP031664:c2506355-2506248 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT109697 NZ_CP031664:2506171-2506231 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References