Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2480819..2481336 Replicon chromosome
Accession NZ_CP031664
Organism Staphylococcus aureus strain 28

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag DD545_RS13040 Protein ID WP_000113262.1
Coordinates 2480819..2481085 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag DD545_RS13045 Protein ID WP_000584499.1
Coordinates 2481085..2481336 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DD545_RS13010 2476245..2476781 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
DD545_RS13015 2477014..2477838 - 825 WP_000572040.1 formate/nitrite transporter family protein -
DD545_RS13020 2478055..2478237 - 183 WP_000230294.1 hypothetical protein -
DD545_RS13025 2478321..2478788 - 468 WP_117207276.1 SRPBCC domain-containing protein -
DD545_RS13030 2478974..2480524 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
DD545_RS13035 2480713..2480784 - 72 Protein_2414 hypothetical protein -
DD545_RS13040 2480819..2481085 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
DD545_RS13045 2481085..2481336 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DD545_RS13050 2481501..2481602 - 102 WP_001791744.1 hypothetical protein -
DD545_RS13055 2481609..2482208 - 600 WP_000162813.1 DsbA family protein -
DD545_RS13060 2482227..2482589 - 363 WP_000819843.1 DUF4467 domain-containing protein -
DD545_RS13065 2482844..2484094 + 1251 WP_117207277.1 FemA/FemB family glycyltransferase FmhA -
DD545_RS13070 2484191..2484922 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
DD545_RS13075 2484919..2485638 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T109696 WP_000113262.1 NZ_CP031664:c2481085-2480819 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T109696 NZ_CP031664:c2481085-2480819 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT109696 WP_000584499.1 NZ_CP031664:c2481336-2481085 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT109696 NZ_CP031664:c2481336-2481085 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References