Detailed information of TA system TA109695

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2215678..2215895
• Replicon: chromosome
• Accession: NZ_CP031664
• Organism: Staphylococcus aureus strain 28

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: DD545_RS11615
• Protein ID: WP_001802298.1
• Coordinates: 2215791..2215895 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2215678..2215733 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DD545_RS11595	2211815..2212480	-	666	WP_117207270.1	SDR family oxidoreductase	-
DD545_RS11600	2212632..2212952	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
DD545_RS11605	2212954..2213934	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
DD545_RS11610	2214200..2215291	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2215678..2215733	+	56	-	-	Antitoxin
DD545_RS11615	2215791..2215895	-	105	WP_001802298.1	hypothetical protein	Toxin
DD545_RS14955	2216056..2216539	-	484	Protein_2148	recombinase family protein	-
DD545_RS11625	2216582..2217718	-	1137	WP_000115564.1	SAP domain-containing protein	-
DD545_RS11630	2218007..2218099	+	93	WP_001790138.1	hypothetical protein	-
DD545_RS11635	2218803..2219660	-	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
DD545_RS11640	2219728..2220510	-	783	WP_117207271.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-85)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T109695 WP_001802298.1 NZ_CP031664:c2215895-2215791 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T109695 NZ_CP031664:c2215895-2215791 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT109695 NZ_CP031664:2215678-2215733 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin