Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2053432..2053846 Replicon chromosome
Accession NZ_CP031664
Organism Staphylococcus aureus strain 28

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DD545_RS10660 Protein ID WP_001065046.1
Coordinates 2053595..2053846 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DD545_RS14950 Protein ID WP_000028424.1
Coordinates 2053432..2053605 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DD545_RS10600 2048996..2049340 - 345 WP_000817289.1 HNH endonuclease -
DD545_RS10605 2049356..2049808 - 453 WP_000406191.1 nucleoside triphosphate pyrophosphohydrolase family protein -
DD545_RS10610 2049923..2050393 - 471 WP_000282758.1 hypothetical protein -
DD545_RS10620 2050416..2050616 - 201 WP_000265041.1 DUF1514 family protein -
DD545_RS10625 2050616..2051266 - 651 WP_001005262.1 hypothetical protein -
DD545_RS10630 2051425..2051574 - 150 WP_000595305.1 transcriptional activator RinB -
DD545_RS10635 2051571..2051957 - 387 WP_000592201.1 hypothetical protein -
DD545_RS10640 2051954..2052160 - 207 WP_000195803.1 DUF1381 domain-containing protein -
DD545_RS10645 2052157..2052402 - 246 WP_001282074.1 hypothetical protein -
DD545_RS10650 2052439..2052972 - 534 WP_001061838.1 dUTP diphosphatase -
DD545_RS14945 2052987..2053148 - 162 WP_000889682.1 hypothetical protein -
DD545_RS10655 2053149..2053406 - 258 WP_000248921.1 hypothetical protein -
DD545_RS14950 2053432..2053605 - 174 WP_000028424.1 hypothetical protein Antitoxin
DD545_RS10660 2053595..2053846 - 252 WP_001065046.1 DUF1024 family protein Toxin
DD545_RS10665 2053861..2054103 - 243 WP_000131381.1 phi PVL orf 51-like protein -
DD545_RS10670 2054107..2054475 - 369 WP_000101270.1 hypothetical protein -
DD545_RS10675 2054488..2054943 - 456 WP_000401965.1 RusA family crossover junction endodeoxyribonuclease -
DD545_RS10680 2054952..2055170 - 219 WP_000338527.1 hypothetical protein -
DD545_RS10685 2055177..2056070 - 894 WP_000148327.1 DnaD domain-containing protein -
DD545_RS10690 2056100..2056570 - 471 WP_000934762.1 single-stranded DNA-binding protein -
DD545_RS10695 2056571..2057188 - 618 WP_072353921.1 MBL fold metallo-hydrolase -
DD545_RS10700 2057269..2058189 - 921 WP_000138475.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / sak / hlb / sell / sec / groEL 2025082..2095474 70392


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9377.26 Da        Isoelectric Point: 3.7128

>T109691 WP_001065046.1 NZ_CP031664:c2053846-2053595 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T109691 NZ_CP031664:c2053846-2053595 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAATCAATTATCAGTGCTAGTGCCTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGGTTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT109691 WP_000028424.1 NZ_CP031664:c2053605-2053432 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT109691 NZ_CP031664:c2053605-2053432 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References