Detailed information of TA system TA109687

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2028721..2029020
• Replicon: chromosome
• Accession: NZ_CP031664
• Organism: Staphylococcus aureus strain 28

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: DD545_RS10495
• Protein ID: WP_072353918.1
• Coordinates: 2028844..2029020 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2028721..2028776 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DD545_RS10435	2024279..2024458	+	180	WP_000669791.1	hypothetical protein	-
DD545_RS10445	2024769..2025029	+	261	WP_001791826.1	hypothetical protein	-
DD545_RS10450	2025082..2025432	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
DD545_RS10455	2025943..2026278	-	336	Protein_1931	SH3 domain-containing protein	-
DD545_RS10475	2026929..2027420	-	492	WP_000920038.1	staphylokinase	-
DD545_RS10480	2027611..2028366	-	756	WP_000861038.1	CHAP domain-containing protein	-
DD545_RS10485	2028378..2028632	-	255	WP_000611512.1	phage holin	-
DD545_RS10490	2028684..2028791	+	108	WP_001791821.1	hypothetical protein	-
-	2028713..2028852	+	140	NuclAT_0	-	-
-	2028713..2028852	+	140	NuclAT_0	-	-
-	2028713..2028852	+	140	NuclAT_0	-	-
-	2028713..2028852	+	140	NuclAT_0	-	-
-	2028721..2028776	+	56	-	-	Antitoxin
DD545_RS10495	2028844..2029020	-	177	WP_072353918.1	putative holin-like toxin	Toxin
DD545_RS10500	2029163..2029537	-	375	WP_000340977.1	hypothetical protein	-
DD545_RS10505	2029593..2029880	-	288	WP_001262620.1	hypothetical protein	-
DD545_RS10510	2029926..2030078	-	153	WP_001000058.1	hypothetical protein	-
DD545_RS10515	2030071..2033853	-	3783	WP_000582132.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / sell / sec / groEL	2025082..2095474	70392

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T109687 WP_072353918.1 NZ_CP031664:c2029020-2028844 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T109687 NZ_CP031664:c2029020-2028844 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGATGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT109687 NZ_CP031664:2028721-2028776 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Antitoxin