Detailed information of TA system TA109681

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1517575..1518154
• Replicon: chromosome
• Accession: NZ_CP031664
• Organism: Staphylococcus aureus strain 28

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: DD545_RS07615
• Protein ID: WP_001025401.1
• Coordinates: 1517909..1518154 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1517575..1517940 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DD545_RS07575	1514319..1514876	-	558	WP_000645048.1	DUF2815 family protein	-
DD545_RS07580	1514902..1516068	-	1167	WP_031893906.1	DUF2800 domain-containing protein	-
DD545_RS07585	1516065..1516427	-	363	WP_000985979.1	hypothetical protein	-
DD545_RS07590	1516442..1516765	-	324	WP_000175000.1	hypothetical protein	-
DD545_RS07595	1516844..1517005	-	162	WP_001285949.1	DUF1270 domain-containing protein	-
DD545_RS07600	1517017..1517280	-	264	WP_001596347.1	helix-turn-helix domain-containing protein	-
DD545_RS07605	1517305..1517520	-	216	WP_001097552.1	hypothetical protein	-
DD545_RS07610	1517575..1517940	+	366	WP_001128433.1	hypothetical protein	Antitoxin
DD545_RS07615	1517909..1518154	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
DD545_RS07620	1518221..1518601	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
DD545_RS07625	1518588..1518785	-	198	WP_001148860.1	hypothetical protein	-
DD545_RS07630	1518855..1519067	+	213	WP_000362644.1	hypothetical protein	-
DD545_RS14935	1519108..1519257	-	150	WP_000771849.1	hypothetical protein	-
DD545_RS07635	1519272..1519637	-	366	WP_117207243.1	hypothetical protein	-
DD545_RS07640	1519685..1519897	-	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
DD545_RS07645	1520049..1520780	+	732	WP_000511090.1	XRE family transcriptional regulator	-
DD545_RS07650	1520851..1521033	+	183	WP_000705240.1	hypothetical protein	-
DD545_RS07655	1521070..1521216	+	147	WP_072403847.1	hypothetical protein	-
DD545_RS07660	1521213..1521827	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	ebp	1468678..1540789	72111

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T109681 WP_001025401.1 NZ_CP031664:c1518154-1517909 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T109681 NZ_CP031664:c1518154-1517909 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT109681 NZ_CP031664:1517575-1517940 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin