Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3827675..3828327 Replicon chromosome
Accession NZ_CP031649
Organism Pantoea agglomerans strain TH81

Toxin (Protein)


Gene name higB Uniprot ID A0A8X8DRT2
Locus tag D0A61_RS18025 Protein ID WP_010672045.1
Coordinates 3827675..3828028 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag D0A61_RS18030 Protein ID WP_083070364.1
Coordinates 3828028..3828327 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0A61_RS18010 3823401..3825185 - 1785 WP_122459458.1 GMC family oxidoreductase -
D0A61_RS18015 3825188..3825922 - 735 WP_010672043.1 gluconate 2-dehydrogenase subunit 3 family protein -
D0A61_RS18020 3826199..3827440 + 1242 WP_010672044.1 peptide antibiotic transporter SbmA -
D0A61_RS18025 3827675..3828028 + 354 WP_010672045.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D0A61_RS18030 3828028..3828327 + 300 WP_083070364.1 XRE family transcriptional regulator Antitoxin
D0A61_RS18035 3828449..3829501 - 1053 WP_033770847.1 YncE family protein -
D0A61_RS18040 3829704..3829913 - 210 WP_009092571.1 DUF1471 domain-containing protein -
D0A61_RS18045 3830126..3831313 - 1188 WP_010252123.1 MFS transporter -
D0A61_RS18050 3831418..3832383 + 966 WP_111534493.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13660.67 Da        Isoelectric Point: 7.9792

>T109610 WP_010672045.1 NZ_CP031649:3827675-3828028 [Pantoea agglomerans]
MWTVLLSPRFESWLSEQEEALQEKMLADLGKLKVYGPDLPRPYADTLKGSQYRNMKELRVQFSGKPIRAFYAFDPVRQAI
VLCAGDKSHDKRFYIRMIRIADDEFSAWLAEQEKGNN

Download         Length: 354 bp

>T109610 NZ_CP031649:3827675-3828028 [Pantoea agglomerans]
ATGTGGACCGTACTCCTGAGCCCGCGCTTTGAAAGCTGGCTAAGTGAGCAGGAAGAAGCCCTGCAGGAAAAAATGTTAGC
GGATCTGGGAAAGTTAAAAGTATACGGCCCTGATTTGCCTCGCCCTTATGCTGATACTCTCAAGGGCTCGCAGTACAGGA
ATATGAAAGAACTCCGCGTACAGTTTTCAGGAAAGCCAATTCGGGCATTTTATGCATTTGACCCTGTCCGCCAGGCTATT
GTGTTATGTGCCGGAGATAAGAGTCATGACAAACGTTTTTATATCCGAATGATACGCATCGCTGACGATGAATTTTCAGC
CTGGCTGGCTGAACAGGAGAAGGGAAATAATTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11131.01 Da        Isoelectric Point: 6.3781

>AT109610 WP_083070364.1 NZ_CP031649:3828028-3828327 [Pantoea agglomerans]
MRTLDDVIADFSPESQARIKKMSDEMILEVGLQMIREELQLSQKTLAEAMGVRQPAVAQIEQRGNEIKVATLKRYIEAMG
GKLSLDVELPTGKRVAFRI

Download         Length: 300 bp

>AT109610 NZ_CP031649:3828028-3828327 [Pantoea agglomerans]
ATGAGAACCCTGGATGATGTTATCGCCGACTTCTCCCCTGAGAGTCAGGCGCGAATCAAAAAAATGTCTGATGAAATGAT
TCTGGAAGTCGGGCTTCAGATGATTCGCGAAGAGCTTCAGTTATCACAAAAGACGCTCGCCGAGGCCATGGGCGTGCGTC
AGCCTGCCGTTGCTCAGATTGAGCAACGCGGAAATGAGATTAAGGTTGCCACGCTGAAACGCTATATCGAAGCAATGGGC
GGAAAACTCAGTCTTGATGTGGAACTTCCGACCGGAAAAAGAGTGGCCTTTCGCATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References