Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1763191..1763921 Replicon chromosome
Accession NZ_CP031649
Organism Pantoea agglomerans strain TH81

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag D0A61_RS08210 Protein ID WP_010258579.1
Coordinates 1763604..1763921 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag D0A61_RS08205 Protein ID WP_039391120.1
Coordinates 1763191..1763523 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0A61_RS08185 1758569..1759210 + 642 WP_003849160.1 protein phosphatase CheZ -
D0A61_RS08190 1759399..1760550 + 1152 WP_010258565.1 flagellar type III secretion system protein FlhB -
D0A61_RS08195 1760543..1762636 + 2094 WP_010670817.1 flagellar biosynthesis protein FlhA -
D0A61_RS08200 1762636..1763028 + 393 WP_050679619.1 flagellar protein FlhE -
D0A61_RS08205 1763191..1763523 - 333 WP_039391120.1 HigA family addiction module antidote protein Antitoxin
D0A61_RS08210 1763604..1763921 - 318 WP_010258579.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D0A61_RS08215 1763996..1764994 - 999 WP_122458295.1 aldo/keto reductase -
D0A61_RS08220 1765207..1766142 - 936 WP_122458297.1 LysR family transcriptional regulator -
D0A61_RS08225 1766231..1767961 - 1731 WP_122458300.1 arginine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12357.17 Da        Isoelectric Point: 10.1380

>T109605 WP_010258579.1 NZ_CP031649:c1763921-1763604 [Pantoea agglomerans]
VATLRNIESFRDDWLKDYFLYGKFSKRIPSSLSSALARKLDMINAAINYKDLRSPPGNRYEELNPPLKGYASIRVNEQYR
LIFKWIEGKAVDLYLDAHSYKTHKR

Download         Length: 318 bp

>T109605 NZ_CP031649:c1763921-1763604 [Pantoea agglomerans]
GTGGCGACGTTAAGGAATATTGAAAGTTTCAGGGATGACTGGCTTAAGGATTATTTTTTATATGGCAAATTTTCTAAAAG
AATACCGTCAAGCCTCTCATCAGCGCTGGCGCGAAAGCTCGACATGATCAATGCGGCGATTAACTATAAGGATTTAAGGT
CGCCGCCTGGCAATCGTTATGAGGAACTAAATCCGCCTCTCAAGGGATATGCTTCAATCAGGGTCAATGAGCAATATCGG
CTGATCTTTAAATGGATAGAAGGTAAGGCCGTTGACCTTTATCTGGATGCTCATAGTTATAAAACGCACAAGCGATGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12587.43 Da        Isoelectric Point: 5.1473

>AT109605 WP_039391120.1 NZ_CP031649:c1763523-1763191 [Pantoea agglomerans]
MNQATRKPTTVGDVLLYEYLEPTGLKILDLAEMLKVHRNTVSALVNNNRKLTPDMAFRLAAAFETSVEFWLNLQNSVDIW
EVMHDARAQEEISRVTPLKDFLAQKENQLA

Download         Length: 333 bp

>AT109605 NZ_CP031649:c1763523-1763191 [Pantoea agglomerans]
ATGAACCAGGCGACCCGCAAACCGACCACTGTCGGTGACGTATTACTTTACGAATATCTGGAGCCAACCGGCCTGAAGAT
TCTCGACTTAGCGGAGATGCTCAAAGTGCACCGCAACACCGTCAGCGCTCTGGTCAACAATAACCGGAAGCTGACGCCGG
ATATGGCTTTCAGGCTGGCTGCAGCTTTCGAAACCAGCGTTGAGTTCTGGCTTAATCTGCAAAACAGTGTCGATATCTGG
GAAGTGATGCATGATGCCAGGGCACAGGAGGAGATCAGTCGCGTAACACCGTTGAAGGATTTTCTGGCGCAGAAAGAGAA
TCAGCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References