Detailed information of TA system TA109604

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1569638..1570298
• Replicon: chromosome
• Accession: NZ_CP031649
• Organism: Pantoea agglomerans strain TH81

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A349IFT5
• Locus tag: D0A61_RS07295
• Protein ID: WP_010670918.1
• Coordinates: 1569638..1569991 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: D0A61_RS07300
• Protein ID: WP_010247918.1
• Coordinates: 1569996..1570298 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D0A61_RS07275	1564835..1565116	+	282	WP_010247933.1	hypothetical protein	-
D0A61_RS07280	1565215..1565616	+	402	WP_010247930.1	hypothetical protein	-
D0A61_RS07285	1565693..1567855	-	2163	WP_122458168.1	ferric-rhodotorulic acid/ferric-coprogen receptor FhuE	-
D0A61_RS07290	1568251..1569339	+	1089	WP_031292657.1	hypothetical protein	-
D0A61_RS07295	1569638..1569991	+	354	WP_010670918.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D0A61_RS07300	1569996..1570298	+	303	WP_010247918.1	XRE family transcriptional regulator	Antitoxin
D0A61_RS07310	1570970..1571893	+	924	WP_122458171.1	sugar ABC transporter substrate-binding protein	-
D0A61_RS07315	1571926..1573410	+	1485	WP_033758305.1	sugar ABC transporter ATP-binding protein	-
D0A61_RS07320	1573434..1574459	+	1026	WP_170933484.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (18-89)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13649.71 Da
• Isoelectric Point: 8.4949

>T109604 WP_010670918.1 NZ_CP031649:1569638-1569991 [Pantoea agglomerans]
VWMIKTTERFDRWFTLLNESDRACVLAALMVLREKGPGLSRPYADTLKGSVYINMKELRIQSRGDPIRAFFAFDPNRTAI
VLCAGNKVGNEKRFYQEMLPVADREFTHWLNSFKDEE

Nucleotide

• Length: 354 bp

>T109604 NZ_CP031649:1569638-1569991 [Pantoea agglomerans]
GTGTGGATGATTAAAACGACGGAGAGGTTTGATCGCTGGTTTACCTTGCTTAATGAGAGCGATCGCGCCTGCGTACTGGC
AGCATTAATGGTGTTGCGCGAAAAAGGGCCGGGGTTGTCCAGGCCATACGCGGATACGCTAAAAGGCTCTGTTTATATCA
ACATGAAAGAGCTGCGTATTCAGAGTCGCGGCGATCCGATAAGGGCTTTCTTTGCTTTTGACCCAAACCGAACGGCGATT
GTGCTTTGTGCCGGAAATAAGGTGGGCAATGAAAAGCGTTTTTATCAGGAGATGCTTCCGGTTGCCGATCGGGAATTTAC
ACACTGGCTGAATAGTTTTAAAGATGAGGAGTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10941.72 Da
• Isoelectric Point: 5.7251

>AT109604 WP_010247918.1 NZ_CP031649:1569996-1570298 [Pantoea agglomerans]
MGRTLEQLIADEKPEVVADAQAMATDILLNIHLAELREKVQKTQVEMAKALGITQPTVAGMEKPGRDLKLSTLKRYIDAA
GGKLRLVVELPDGSHYGFEV

Nucleotide

• Length: 303 bp

>AT109604 NZ_CP031649:1569996-1570298 [Pantoea agglomerans]
ATGGGCAGAACGCTTGAACAGCTTATTGCGGATGAAAAACCGGAAGTCGTTGCCGACGCCCAGGCGATGGCGACGGATAT
CCTGCTCAACATTCACCTTGCCGAGCTGCGTGAGAAAGTGCAGAAAACACAGGTCGAAATGGCAAAGGCGCTGGGCATTA
CACAGCCTACCGTGGCGGGTATGGAAAAGCCGGGCCGCGATCTGAAGCTCTCCACGCTCAAGCGCTATATCGATGCGGCA
GGGGGTAAGCTGCGGCTGGTGGTGGAACTGCCGGACGGCTCGCACTACGGGTTTGAGGTGTAA

Structures

Toxin

• AlphaFold DB: A0A349IFT5