Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 160976..161234 Replicon chromosome
Accession NZ_CP031609
Organism Escherichia coli strain N3

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag AXA56_RS00755 Protein ID WP_000809168.1
Coordinates 161082..161234 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 160976..161033 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXA56_RS00740 157368..158327 + 960 WP_042003960.1 hypothetical protein -
AXA56_RS00745 158365..159264 - 900 WP_001300855.1 transcriptional activator NhaR -
AXA56_RS00750 159330..160496 - 1167 WP_116836082.1 Na+/H+ antiporter NhaA -
- 160976..161033 - 58 - - Antitoxin
AXA56_RS00755 161082..161234 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
AXA56_RS00760 161339..162469 - 1131 WP_001118464.1 molecular chaperone DnaJ -
AXA56_RS00765 162558..164474 - 1917 WP_000516135.1 molecular chaperone DnaK -
AXA56_RS00770 164850..165254 + 405 WP_000843578.1 DUF2541 family protein -
AXA56_RS00775 165280..165984 + 705 WP_001102363.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T109523 WP_000809168.1 NZ_CP031609:161082-161234 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T109523 NZ_CP031609:161082-161234 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCTGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT109523 NZ_CP031609:c161033-160976 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References