Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5025854..5026443 Replicon chromosome
Accession NZ_CP031607
Organism Xanthomonas hortorum strain VT106

Toxin (Protein)


Gene name graT Uniprot ID A0A6V7BZM8
Locus tag DYQ48_RS22360 Protein ID WP_074058684.1
Coordinates 5026162..5026443 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0Q5FN17
Locus tag DYQ48_RS22355 Protein ID WP_055829449.1
Coordinates 5025854..5026144 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DYQ48_RS22330 5021283..5022608 + 1326 WP_154845000.1 hypothetical protein -
DYQ48_RS22335 5023001..5023333 + 333 WP_074058681.1 hypothetical protein -
DYQ48_RS22345 5023951..5024853 - 903 WP_074058682.1 AraC family transcriptional regulator -
DYQ48_RS22350 5024988..5025731 + 744 WP_074058683.1 SDR family oxidoreductase -
DYQ48_RS22355 5025854..5026144 - 291 WP_055829449.1 HigA family addiction module antidote protein Antitoxin
DYQ48_RS22360 5026162..5026443 - 282 WP_074058684.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DYQ48_RS22365 5026658..5027713 - 1056 WP_074058685.1 virulence RhuM family protein -
DYQ48_RS22370 5027852..5030095 - 2244 WP_154845001.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11031.71 Da        Isoelectric Point: 10.2121

>T109522 WP_074058684.1 NZ_CP031607:c5026443-5026162 [Xanthomonas hortorum]
MIRSFVDKEAEKIWLGERSRRLPADIQSVARRKLRMLNAAAHLDDLRIPPANRLEALKGQRRGQYSIRINDQWRICFRWM
EGDVAEVDIVDYH

Download         Length: 282 bp

>T109522 NZ_CP031607:c5026443-5026162 [Xanthomonas hortorum]
ATGATAAGGAGCTTTGTCGACAAGGAAGCCGAAAAGATCTGGTTGGGTGAGCGCTCCCGCCGGTTGCCGGCCGACATCCA
GTCGGTCGCGCGCCGCAAGTTGCGCATGCTCAACGCTGCCGCGCACCTCGACGATCTGCGTATTCCACCTGCCAACCGGC
TGGAAGCGTTGAAGGGCCAGCGACGCGGGCAGTACAGCATCCGGATCAACGACCAGTGGCGCATCTGCTTCCGATGGATG
GAGGGCGATGTCGCCGAGGTCGACATCGTCGATTACCACTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10497.17 Da        Isoelectric Point: 6.4675

>AT109522 WP_055829449.1 NZ_CP031607:c5026144-5025854 [Xanthomonas hortorum]
MTVLPNIHPGEILLEEFLEPMGISQNALARATAVPPRRINEIVLGKRGITADTAVRLAAALGTTERFWLGLQADYELEEA
HRALGDLPSRIKRLAA

Download         Length: 291 bp

>AT109522 NZ_CP031607:c5026144-5025854 [Xanthomonas hortorum]
ATGACAGTCCTACCCAACATCCACCCCGGCGAAATCCTGCTTGAGGAGTTTCTCGAGCCGATGGGCATCAGCCAGAACGC
ACTGGCGCGGGCCACCGCCGTGCCGCCGCGCCGCATCAACGAGATCGTGCTGGGCAAGCGCGGCATCACCGCCGACACCG
CCGTGCGCCTGGCCGCAGCGCTGGGCACGACCGAGCGCTTCTGGTTGGGCCTGCAGGCCGACTACGAGCTGGAAGAAGCG
CACCGCGCGCTGGGCGACCTGCCGTCACGGATCAAGCGGCTGGCGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6V7BZM8

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q5FN17

References