Detailed information of TA system TA109518

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-VapI
• Location: 2326864..2327379
• Replicon: chromosome
• Accession: NZ_CP031607
• Organism: Xanthomonas hortorum strain VT106

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: DYQ48_RS09940
• Protein ID: WP_154844615.1
• Coordinates: 2326864..2327070 (+)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DYQ48_RS09945
• Protein ID: WP_023903908.1
• Coordinates: 2327080..2327379 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DYQ48_RS09920	2322184..2323434	-	1251	WP_154844613.1	chemotaxis protein CheW	-
DYQ48_RS09925	2323431..2324213	-	783	WP_154844614.1	ParA family protein	-
DYQ48_RS09930	2324215..2325204	-	990	WP_006452731.1	flagellar motor protein MotD	-
DYQ48_RS09935	2325212..2325952	-	741	WP_006452732.1	flagellar motor protein	-
DYQ48_RS09940	2326864..2327070	+	207	WP_154844615.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DYQ48_RS09945	2327080..2327379	+	300	WP_023903908.1	HigA family addiction module antidote protein	Antitoxin
DYQ48_RS09950	2327549..2329207	-	1659	WP_055826896.1	chemotaxis protein CheA	-
DYQ48_RS09955	2329210..2329836	-	627	WP_006450905.1	protein phosphatase CheZ	-
DYQ48_RS09960	2329836..2330228	-	393	WP_002813536.1	chemotaxis response regulator CheY	-
DYQ48_RS09965	2330264..2331037	-	774	WP_023903918.1	RNA polymerase sigma factor FliA	-
DYQ48_RS09970	2331034..2331918	-	885	WP_006451802.1	MinD/ParA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (3-68)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (4-88)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7784.81 Da
• Isoelectric Point: 6.2041

>T109518 WP_154844615.1 NZ_CP031607:2326864-2327070 [Xanthomonas hortorum]
MQAVAERKLQLLDSAQTLEFLRSPPGNRLELLAGTRAGQHSIRINDQWRVCFVWTDAGPEHVEIVDYH

Nucleotide

• Length: 207 bp

>T109518 NZ_CP031607:2326864-2327070 [Xanthomonas hortorum]
ATGCAAGCTGTAGCCGAACGGAAGCTGCAATTGCTGGATTCGGCGCAGACGCTGGAGTTCTTGCGCAGCCCGCCGGGCAA
TCGGCTTGAGCTTCTTGCGGGTACGCGTGCAGGTCAGCACAGCATCCGCATCAATGACCAATGGCGTGTGTGCTTTGTCT
GGACTGACGCCGGCCCCGAGCACGTTGAGATTGTCGATTACCACTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10903.58 Da
• Isoelectric Point: 10.7753

>AT109518 WP_023903908.1 NZ_CP031607:2327080-2327379 [Xanthomonas hortorum]
MRLTNKLRAIHPGEILREDFMLPLGLTINGLARALDVPATRIHSIVHGERAISADTAARLARHFGGDAASWLALQATYEL
KTLPNRSEIERNVQPRVAA

Nucleotide

• Length: 300 bp

>AT109518 NZ_CP031607:2327080-2327379 [Xanthomonas hortorum]
ATGCGACTCACCAACAAACTGCGCGCCATCCATCCTGGCGAAATCCTGCGGGAAGATTTCATGCTGCCGCTGGGGCTGAC
CATCAACGGCCTGGCGCGGGCGCTGGATGTACCGGCAACGCGCATCCACAGCATCGTGCATGGCGAGCGTGCCATCAGCG
CCGATACCGCAGCGCGGCTTGCACGCCACTTCGGTGGCGATGCGGCGTCCTGGCTCGCGCTGCAGGCCACGTATGAACTC
AAGACCTTGCCCAACCGCAGCGAGATCGAGCGCAACGTGCAGCCGCGTGTGGCGGCCTAG