Detailed information of TA system TA109507

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 429082..429605
• Replicon: chromosome
• Accession: NZ_CP031605
• Organism: Staphylococcus pseudintermedius strain VB16

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: DRC71_RS01935
• Protein ID: WP_015729746.1
• Coordinates: 429339..429605 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A2P5PI69
• Locus tag: DRC71_RS01930
• Protein ID: WP_015729747.1
• Coordinates: 429082..429339 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DRC71_RS01910 (DRC71_01960)	424421..424603	-	183	WP_096536006.1	hypothetical protein	-
DRC71_RS01915 (DRC71_01965)	425130..425918	+	789	WP_140237250.1	arylamine N-acetyltransferase	-
DRC71_RS01920 (DRC71_01970)	426230..426724	-	495	WP_015729749.1	isoprenylcysteine carboxylmethyltransferase family protein	-
DRC71_RS01925 (DRC71_01975)	426984..428888	+	1905	WP_015729748.1	triacylglycerol lipase	-
DRC71_RS01930 (DRC71_01980)	429082..429339	+	258	WP_015729747.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DRC71_RS01935 (DRC71_01985)	429339..429605	+	267	WP_015729746.1	Txe/YoeB family addiction module toxin	Toxin
DRC71_RS01940 (DRC71_01990)	429966..430067	-	102	WP_019169745.1	SE2200 family small protein	-
DRC71_RS01945 (DRC71_01995)	430081..431574	-	1494	WP_014612817.1	L-lactate dehydrogenase (quinone)	-
DRC71_RS13535	432331..432425	+	95	Protein_388	KxYKxGKxW signal peptide domain-containing protein	-
DRC71_RS13540	433865..434434	-	570	WP_206665916.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (9-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10541.08 Da
• Isoelectric Point: 10.1602

>T109507 WP_015729746.1 NZ_CP031605:429339-429605 [Staphylococcus pseudintermedius]
MGNYSVLIKNSAKNDLKKIKKSLLKEQFSKIIEVLKVNPYEASQSFEKLQPKHSARYSRRLNHQHRVVYTVDDEKREVYI
FSAWSYYE

Nucleotide

• Length: 267 bp

>T109507 NZ_CP031605:429339-429605 [Staphylococcus pseudintermedius]
ATGGGTAATTATTCTGTCTTAATTAAGAATTCAGCCAAAAATGACTTGAAAAAAATTAAAAAGTCACTTCTTAAAGAGCA
ATTTTCAAAAATTATTGAAGTTTTAAAGGTTAACCCTTATGAAGCTAGTCAATCTTTTGAGAAGCTACAACCGAAGCATT
CAGCTCGATATTCAAGGCGTCTGAATCATCAACATAGAGTTGTGTATACGGTTGATGATGAAAAAAGAGAAGTTTATATT
TTTTCTGCTTGGTCATATTATGAGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9836.85 Da
• Isoelectric Point: 4.1100

>AT109507 WP_015729747.1 NZ_CP031605:429082-429339 [Staphylococcus pseudintermedius]
MIIKTPTNARKEFYELLKQVNDNHEPIIISGSKSENNAVIVSQEDWDGIQETLFLEYTGTMDKVRAREKDDSGYTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT109507 NZ_CP031605:429082-429339 [Staphylococcus pseudintermedius]
ATGATTATTAAAACGCCTACAAATGCTAGAAAAGAGTTTTACGAGTTGTTAAAACAAGTTAATGATAATCATGAGCCTAT
TATAATAAGTGGTTCTAAAAGTGAAAACAATGCAGTTATTGTTAGTCAGGAAGACTGGGATGGTATTCAAGAAACGTTAT
TTCTCGAATACACTGGTACTATGGATAAAGTAAGAGCACGTGAAAAAGATGATAGTGGTTATACCAATATTGACGATATA
GATTGGGATAATTTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A2P5PI69