Detailed information of TA system TA109501

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1285402..1285925
• Replicon: chromosome
• Accession: NZ_CP031603
• Organism: Staphylococcus pseudintermedius strain AK9

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: DNI27_RS06015
• Protein ID: WP_015729746.1
• Coordinates: 1285659..1285925 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A2P5PI69
• Locus tag: DNI27_RS06010
• Protein ID: WP_015729747.1
• Coordinates: 1285402..1285659 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DNI27_RS05990 (DNI27_06125)	1280741..1280923	-	183	WP_096536006.1	hypothetical protein	-
DNI27_RS05995 (DNI27_06130)	1281450..1282238	+	789	WP_140237250.1	arylamine N-acetyltransferase	-
DNI27_RS06000 (DNI27_06135)	1282550..1283044	-	495	WP_015729749.1	isoprenylcysteine carboxylmethyltransferase family protein	-
DNI27_RS06005 (DNI27_06140)	1283304..1285208	+	1905	WP_015729748.1	triacylglycerol lipase	-
DNI27_RS06010 (DNI27_06145)	1285402..1285659	+	258	WP_015729747.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DNI27_RS06015 (DNI27_06150)	1285659..1285925	+	267	WP_015729746.1	Txe/YoeB family addiction module toxin	Toxin
DNI27_RS06020 (DNI27_06155)	1286286..1286387	-	102	WP_019169745.1	SE2200 family small protein	-
DNI27_RS06025 (DNI27_06160)	1286401..1287894	-	1494	WP_014612817.1	L-lactate dehydrogenase (quinone)	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (9-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10541.08 Da
• Isoelectric Point: 10.1602

>T109501 WP_015729746.1 NZ_CP031603:1285659-1285925 [Staphylococcus pseudintermedius]
MGNYSVLIKNSAKNDLKKIKKSLLKEQFSKIIEVLKVNPYEASQSFEKLQPKHSARYSRRLNHQHRVVYTVDDEKREVYI
FSAWSYYE

Nucleotide

• Length: 267 bp

>T109501 NZ_CP031603:1285659-1285925 [Staphylococcus pseudintermedius]
ATGGGTAATTATTCTGTCTTAATTAAGAATTCAGCCAAAAATGACTTGAAAAAAATTAAAAAGTCACTTCTTAAAGAGCA
ATTTTCAAAAATTATTGAAGTTTTAAAGGTTAACCCTTATGAAGCTAGTCAATCTTTTGAGAAGCTACAACCGAAGCATT
CAGCTCGATATTCAAGGCGTCTGAATCATCAACATAGAGTTGTGTATACGGTTGATGATGAAAAAAGAGAAGTTTATATT
TTTTCTGCTTGGTCATATTATGAGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9836.85 Da
• Isoelectric Point: 4.1100

>AT109501 WP_015729747.1 NZ_CP031603:1285402-1285659 [Staphylococcus pseudintermedius]
MIIKTPTNARKEFYELLKQVNDNHEPIIISGSKSENNAVIVSQEDWDGIQETLFLEYTGTMDKVRAREKDDSGYTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT109501 NZ_CP031603:1285402-1285659 [Staphylococcus pseudintermedius]
ATGATTATTAAAACGCCTACAAATGCTAGAAAAGAGTTTTACGAGTTGTTAAAACAAGTTAATGATAATCATGAGCCTAT
TATAATAAGTGGTTCTAAAAGTGAAAACAATGCAGTTATTGTTAGTCAGGAAGACTGGGATGGTATTCAAGAAACGTTAT
TTCTCGAATACACTGGTACTATGGATAAAGTAAGAGCACGTGAAAAAGATGATAGTGGTTATACCAATATTGACGATATA
GATTGGGATAATTTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A2P5PI69