Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2633319..2633842 Replicon chromosome
Accession NZ_CP031561
Organism Staphylococcus pseudintermedius strain AP20

Toxin (Protein)


Gene name yoeB Uniprot ID A0A317Z6J3
Locus tag DNI88_RS12710 Protein ID WP_037542127.1
Coordinates 2633576..2633842 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2P5PI69
Locus tag DNI88_RS12705 Protein ID WP_015729747.1
Coordinates 2633319..2633576 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DNI88_RS12695 (DNI88_12775) 2630466..2630960 - 495 WP_037542124.1 isoprenylcysteine carboxylmethyltransferase family protein -
DNI88_RS12700 (DNI88_12780) 2631220..2633124 + 1905 WP_037542126.1 triacylglycerol lipase -
DNI88_RS12705 (DNI88_12785) 2633319..2633576 + 258 WP_015729747.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DNI88_RS12710 (DNI88_12790) 2633576..2633842 + 267 WP_037542127.1 Txe/YoeB family addiction module toxin Toxin
DNI88_RS12715 (DNI88_12795) 2634203..2634304 - 102 WP_019169745.1 SE2200 family small protein -
DNI88_RS12720 (DNI88_12800) 2634318..2635811 - 1494 WP_014612817.1 L-lactate dehydrogenase (quinone) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10555.10 Da        Isoelectric Point: 10.1602

>T109421 WP_037542127.1 NZ_CP031561:2633576-2633842 [Staphylococcus pseudintermedius]
MGNYSVLIKNSAKNDLKKIKKSLLKEQFSKIIEVLKINPYEASQSFEKLQPKHSARYSRRLNHQHRVVYTVDDEKREVYI
FSAWSYYE

Download         Length: 267 bp

>T109421 NZ_CP031561:2633576-2633842 [Staphylococcus pseudintermedius]
ATGGGTAATTATTCTGTCTTAATTAAGAATTCAGCCAAAAATGACTTGAAAAAAATTAAAAAGTCACTTCTTAAAGAGCA
ATTTTCAAAAATTATTGAAGTTTTAAAGATTAACCCTTATGAAGCTAGTCAATCTTTTGAGAAGCTACAACCGAAGCATT
CAGCTCGATATTCAAGGCGTCTGAATCATCAACATAGAGTTGTGTATACGGTTGATGATGAAAAAAGAGAAGTTTATATT
TTTTCTGCTTGGTCATATTATGAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9836.85 Da        Isoelectric Point: 4.1100

>AT109421 WP_015729747.1 NZ_CP031561:2633319-2633576 [Staphylococcus pseudintermedius]
MIIKTPTNARKEFYELLKQVNDNHEPIIISGSKSENNAVIVSQEDWDGIQETLFLEYTGTMDKVRAREKDDSGYTNIDDI
DWDNL

Download         Length: 258 bp

>AT109421 NZ_CP031561:2633319-2633576 [Staphylococcus pseudintermedius]
ATGATTATTAAAACGCCTACAAATGCTAGAAAAGAGTTTTACGAGTTGTTAAAACAAGTTAATGATAATCATGAGCCTAT
TATAATAAGTGGTTCTAAAAGTGAAAACAATGCAGTTATTGTTAGTCAGGAAGACTGGGATGGTATTCAAGAAACGTTAT
TTCTCGAATACACTGGTACTATGGATAAAGTAAGAGCACGTGAAAAAGATGATAGTGGTTATACCAATATTGACGATATA
GATTGGGATAATTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A317Z6J3

Antitoxin

Source ID Structure
AlphaFold DB A0A2P5PI69

References