Detailed information of TA system TA109326

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 735564..735863
• Replicon: chromosome
• Accession: NZ_CP031537
• Organism: Staphylococcus aureus strain WCH-SK2

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: LR49_RS03925
• Protein ID: WP_072482930.1
• Coordinates: 735687..735863 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	735564..735619 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LR49_RS03870	731122..731301	+	180	WP_000669789.1	hypothetical protein	-
LR49_RS03880	731612..731872	+	261	WP_001791826.1	hypothetical protein	-
LR49_RS03885	731925..732275	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
LR49_RS03890	732785..733120	-	336	Protein_695	SH3 domain-containing protein	-
LR49_RS03905	733772..734263	-	492	WP_000920041.1	staphylokinase	-
LR49_RS03910	734454..735209	-	756	WP_000861038.1	CHAP domain-containing protein	-
LR49_RS03915	735221..735475	-	255	WP_000611512.1	phage holin	-
LR49_RS03920	735527..735634	+	108	Protein_699	hypothetical protein	-
-	735556..735695	+	140	NuclAT_0	-	-
-	735556..735695	+	140	NuclAT_0	-	-
-	735556..735695	+	140	NuclAT_0	-	-
-	735556..735695	+	140	NuclAT_0	-	-
-	735564..735619	+	56	-	-	Antitoxin
LR49_RS03925	735687..735863	-	177	WP_072482930.1	putative holin-like toxin	Toxin
LR49_RS03930	735972..736745	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
LR49_RS03935	737118..737492	-	375	WP_000340977.1	hypothetical protein	-
LR49_RS03940	737548..737835	-	288	WP_001262621.1	hypothetical protein	-
LR49_RS03945	737881..738033	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / groEL	731925..806747	74822
	-	flank	IS/Tn	-	-	729803..730975	1172

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T109326 WP_072482930.1 NZ_CP031537:c735863-735687 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T109326 NZ_CP031537:c735863-735687 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTCATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT109326 NZ_CP031537:735564-735619 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin