Detailed information of TA system TA109305

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ-RelB
• Location: 528908..529424
• Replicon: chromosome
• Accession: NZ_CP031513
• Organism: Bombilactobacillus bombi strain BI-2.5

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: -
• Locus tag: DS830_RS02790
• Protein ID: WP_118908156.1
• Coordinates: 528908..529189 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: -
• Locus tag: DS830_RS02795
• Protein ID: WP_118908157.1
• Coordinates: 529182..529424 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DS830_RS02765	525689..525895	+	207	WP_118908152.1	hypothetical protein	-
DS830_RS02770	526126..526890	+	765	WP_118908153.1	hypothetical protein	-
DS830_RS02775	526905..527600	+	696	WP_162887482.1	AAA family ATPase	-
DS830_RS02780	527653..528071	+	419	Protein_501	DUF1906 domain-containing protein	-
DS830_RS02785	528114..528809	-	696	WP_118908155.1	hypothetical protein	-
DS830_RS02790	528908..529189	-	282	WP_118908156.1	type II toxin-antitoxin system YafQ family toxin	Toxin
DS830_RS02795	529182..529424	-	243	WP_118908157.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
DS830_RS02800	530029..530412	-	384	WP_118908158.1	hypothetical protein	-
DS830_RS02805	530405..531706	-	1302	WP_118908159.1	Y-family DNA polymerase	-
DS830_RS02810	531787..532362	-	576	WP_205526797.1	hypothetical protein	-
DS830_RS02815	532652..533029	+	378	WP_118908161.1	carboxymuconolactone decarboxylase family protein	-
DS830_RS02820	532995..533789	+	795	WP_118909088.1	NAD-dependent deacetylase	-
DS830_RS02825	533851..534222	-	372	WP_118908162.1	MerR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (6-93)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-58)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11459.14 Da
• Isoelectric Point: 9.4146

>T109305 WP_118908156.1 NZ_CP031513:c529189-528908 [Bombilactobacillus bombi]
MTNFVYKPAFERQFKKHYKAILRGGHYKKEDFETVYYKLLQDKPLEPHYNDYPLVNRKPERDLHIKPDWLLIYKYDGEFI
RFIETGSHSDLFK

Nucleotide

• Length: 282 bp

>T109305 NZ_CP031513:c529189-528908 [Bombilactobacillus bombi]
ATGACTAATTTTGTATATAAACCTGCCTTTGAACGCCAGTTTAAAAAGCACTATAAAGCGATACTGCGAGGGGGTCATTA
TAAAAAAGAGGATTTTGAAACTGTTTATTATAAATTGTTACAAGATAAACCGTTAGAGCCACATTATAACGATTACCCTT
TGGTGAATAGAAAGCCAGAGCGTGATTTACATATTAAACCAGATTGGTTATTGATTTATAAATATGACGGCGAATTTATA
CGTTTCATTGAAACTGGTTCCCATTCAGATCTTTTTAAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9233.55 Da
• Isoelectric Point: 7.0138

>AT109305 WP_118908157.1 NZ_CP031513:c529424-529182 [Bombilactobacillus bombi]
MKSQVHFRMDDKEKKDFEIVLKRVGLTPGEAFRIFAKKSIEAGGIPFEVSQPTSRLKTAMKSQDYLEFNNPEEGLNWLND

Nucleotide

• Length: 243 bp

>AT109305 NZ_CP031513:c529424-529182 [Bombilactobacillus bombi]
ATGAAGAGCCAAGTACATTTTAGAATGGATGATAAAGAAAAAAAAGACTTTGAAATCGTCCTTAAACGCGTGGGTTTAAC
CCCTGGTGAGGCATTTCGTATATTTGCCAAAAAATCTATTGAAGCAGGTGGAATCCCATTTGAGGTGTCTCAACCTACTT
CACGTTTAAAAACAGCTATGAAAAGTCAAGATTATCTTGAATTTAATAATCCTGAGGAAGGTTTGAACTGGTTAAATGAC
TAA