Detailed information of TA system TA109257

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1711578..1712278
• Replicon: chromosome
• Accession: NZ_CP031466
• Organism: Paraburkholderia caffeinilytica strain CF1

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: DSC91_RS07595
• Protein ID: WP_115777556.1
• Coordinates: 1711982..1712278 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: DSC91_RS07590
• Protein ID: WP_115777555.1
• Coordinates: 1711578..1711979 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DSC91_RS07580	1706957..1710484	-	3528	WP_115777553.1	DEAD/DEAH box helicase	-
DSC91_RS07585	1710694..1711473	-	780	WP_115777554.1	DeoR/GlpR family DNA-binding transcription regulator	-
DSC91_RS07590	1711578..1711979	-	402	WP_115777555.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
DSC91_RS07595	1711982..1712278	-	297	WP_115777556.1	type II toxin-antitoxin system MqsR family toxin	Toxin
DSC91_RS07600	1712445..1714949	+	2505	WP_115777557.1	FAD-dependent oxidoreductase	-
DSC91_RS07605	1714946..1715485	-	540	WP_115777558.1	cytochrome b	-
DSC91_RS07610	1715482..1715700	-	219	Protein_1498	catalase	-
DSC91_RS07615	1715919..1716188	-	270	WP_115777559.1	DUF4148 domain-containing protein	-
DSC91_RS07620	1716356..1717081	+	726	WP_115777560.1	transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (74-127)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10878.72 Da
• Isoelectric Point: 8.5012

>T109257 WP_115777556.1 NZ_CP031466:c1712278-1711982 [Paraburkholderia caffeinilytica]
MEKNTPHCKLADAQGLARAGKIRITKSAVIGAAALGFGPDVIVETLMSLDRRAFRKSMTTYADHRVWQDVYCAMTEAGMV
YLKLTVVDDVLVVSFKEW

Nucleotide

• Length: 297 bp

>T109257 NZ_CP031466:c1712278-1711982 [Paraburkholderia caffeinilytica]
ATGGAAAAAAATACGCCTCACTGCAAATTGGCCGATGCTCAGGGCCTCGCGCGCGCAGGAAAAATCAGAATCACGAAATC
GGCCGTGATTGGGGCTGCGGCACTCGGCTTCGGGCCTGACGTCATTGTCGAAACTCTGATGTCGCTTGATCGGCGTGCTT
TCAGAAAAAGCATGACTACGTACGCGGATCATCGGGTCTGGCAGGACGTCTACTGCGCCATGACTGAAGCAGGCATGGTC
TATTTGAAATTGACGGTGGTCGATGACGTCCTCGTCGTGTCATTCAAGGAGTGGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14668.83 Da
• Isoelectric Point: 5.2787

>AT109257 WP_115777555.1 NZ_CP031466:c1711979-1711578 [Paraburkholderia caffeinilytica]
MKCPNCGAAELVRDTRNMRYVYKGETAVFEAVTGDYCPACDEAVLDMDEATRTGQMMLAFNKEVNASQVDPAFIAAVRKK
LDLDQREAAEIFGGGVNAFSRYENGKTRPPLALIKLLKVLDRHPELLAEVRAG

Nucleotide

• Length: 402 bp

>AT109257 NZ_CP031466:c1711979-1711578 [Paraburkholderia caffeinilytica]
ATGAAATGCCCGAACTGCGGAGCGGCCGAACTGGTACGCGATACGCGCAATATGCGCTATGTCTACAAAGGGGAGACGGC
CGTCTTCGAGGCCGTCACCGGCGACTATTGCCCGGCATGCGACGAGGCAGTACTCGACATGGACGAGGCGACCCGCACGG
GTCAAATGATGCTGGCCTTCAACAAAGAGGTGAATGCATCTCAAGTGGATCCCGCATTCATTGCCGCCGTCCGCAAGAAA
CTCGATCTGGACCAGCGCGAGGCGGCGGAGATTTTTGGCGGCGGGGTGAATGCTTTTTCGCGGTATGAGAATGGCAAGAC
GAGGCCGCCGCTCGCACTGATCAAACTGTTGAAGGTACTGGACCGGCATCCCGAATTGCTGGCGGAAGTGAGAGCCGGCT
GA