Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4075710..4076404 Replicon chromosome
Accession NZ_CP031396
Organism Pseudomonas protegens strain FD6

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DWF74_RS18460 Protein ID WP_115581455.1
Coordinates 4075710..4075973 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DWF74_RS18465 Protein ID WP_115581456.1
Coordinates 4076003..4076404 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DWF74_RS18435 4071656..4072426 + 771 WP_102862830.1 ParA family protein -
DWF74_RS18440 4072474..4072908 - 435 WP_102862831.1 thioredoxin TrxC -
DWF74_RS18445 4072987..4073937 - 951 WP_115581453.1 hypothetical protein -
DWF74_RS18450 4073964..4074908 - 945 WP_102862833.1 hypothetical protein -
DWF74_RS18455 4074985..4075425 - 441 WP_115581454.1 intracellular growth attenuator family protein -
DWF74_RS18460 4075710..4075973 + 264 WP_115581455.1 type II toxin-antitoxin system HigB family toxin Toxin
DWF74_RS18465 4076003..4076404 + 402 WP_115581456.1 transcriptional regulator Antitoxin
DWF74_RS18470 4076406..4077869 - 1464 WP_102862837.1 YdiU family protein -
DWF74_RS18475 4077919..4081272 - 3354 WP_102862838.1 mechanosensitive channel MscK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-87)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-132)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 9955.63 Da        Isoelectric Point: 10.9550

>T109175 WP_115581455.1 NZ_CP031396:4075710-4075973 [Pseudomonas protegens]
MHIVTAKRIRQAKEQWPQVARALDTWYRKAKGARPADFADMKALFPALDKVGGFHVFDLGGNKLRLIAIVRYGGQRLYIR
HVLDHGE

Download         Length: 264 bp

>T109175 NZ_CP031396:4075710-4075973 [Pseudomonas protegens]
ATGCACATCGTCACCGCAAAACGTATCCGGCAGGCCAAGGAGCAATGGCCGCAAGTCGCGCGGGCGCTGGATACCTGGTA
TCGCAAGGCCAAAGGCGCCAGGCCGGCTGATTTCGCCGATATGAAGGCCTTGTTCCCGGCGCTAGACAAGGTCGGGGGCT
TTCATGTTTTCGACCTTGGCGGCAACAAACTGAGGCTGATCGCAATCGTGCGCTATGGGGGGCAGCGCCTCTATATCAGG
CATGTGCTGGATCACGGCGAATAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14948.12 Da        Isoelectric Point: 4.5603

>AT109175 WP_115581456.1 NZ_CP031396:4076003-4076404 [Pseudomonas protegens]
MSLQVKQAAEHWPFVAPILRKPKSEADYDALALVLDELLDIMGEDESHPLASLVDIMGDWIEAYDEEHHPMPAVSAVEVL
RSLMREHGLTQSDLPGVGAQSVVSEVLSGKRQLNLRQIRWLAERFKLSMETFA

Download         Length: 402 bp

>AT109175 NZ_CP031396:4076003-4076404 [Pseudomonas protegens]
ATGAGTCTTCAGGTTAAGCAAGCGGCGGAGCACTGGCCGTTCGTTGCGCCCATATTGCGCAAACCCAAGAGCGAGGCCGA
TTACGACGCGCTGGCCCTGGTACTCGATGAGCTGTTGGACATCATGGGCGAAGACGAATCGCACCCACTGGCTTCGCTGG
TGGACATCATGGGTGACTGGATCGAGGCCTACGACGAAGAGCACCATCCGATGCCGGCGGTCAGCGCAGTGGAGGTTCTA
CGTTCGTTGATGCGTGAACATGGCCTGACTCAAAGCGACCTGCCCGGGGTGGGCGCGCAGTCGGTGGTCTCGGAAGTGCT
CAGCGGCAAGCGCCAGCTCAACCTGCGGCAGATCCGCTGGCTGGCCGAGCGCTTCAAGCTGTCGATGGAGACCTTCGCCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References