109160

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2012175..2012694 Replicon chromosome
Accession NZ_CP031379
Organism Streptococcus suis strain ISU2660

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0K2E7Z7
Locus tag DK878_RS09905 Protein ID WP_013730620.1
Coordinates 2012175..2012432 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag DK878_RS09910 Protein ID WP_002939010.1
Coordinates 2012434..2012694 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK878_RS09890 2008646..2010376 - 1731 WP_009910905.1 membrane protein -
DK878_RS09895 2010739..2011647 - 909 WP_079399338.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
DK878_RS09900 2011631..2012161 - 531 WP_009910909.1 DUF1697 domain-containing protein -
DK878_RS09905 2012175..2012432 - 258 WP_013730620.1 Txe/YoeB family addiction module toxin Toxin
DK878_RS09910 2012434..2012694 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DK878_RS09915 2012770..2013225 - 456 WP_013730621.1 8-oxo-dGTP diphosphatase -
DK878_RS09920 2013229..2013597 - 369 WP_013730622.1 hypothetical protein -
DK878_RS09925 2013590..2014159 - 570 WP_022540720.1 ribonuclease M5 -
DK878_RS09930 2014143..2014925 - 783 WP_002939015.1 TatD family hydrolase -
DK878_RS09935 2015033..2015170 - 138 WP_002939016.1 50S ribosomal protein L34 -
DK878_RS09940 2015338..2016333 - 996 WP_013730624.1 protein jag -
DK878_RS09945 2016353..2017165 - 813 WP_004194552.1 YidC/Oxa1 family membrane protein insertase -
DK878_RS09950 2017149..2017508 - 360 WP_013730625.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.86 Da        Isoelectric Point: 8.0279

>T109160 WP_013730620.1 NZ_CP031379:c2012432-2012175 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

>T109160 NZ_CP031379:c2012432-2012175 [Streptococcus suis]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCAAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT109160 WP_002939010.1 NZ_CP031379:c2012694-2012434 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT109160 NZ_CP031379:c2012694-2012434 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E7Z7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References