Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1984722..1985241 Replicon chromosome
Accession NZ_CP031377
Organism Streptococcus suis strain ISU2614

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0K2E7Z7
Locus tag DK237_RS09950 Protein ID WP_013730620.1
Coordinates 1984722..1984979 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag DK237_RS09955 Protein ID WP_002939010.1
Coordinates 1984981..1985241 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK237_RS09935 1981193..1982923 - 1731 WP_009910905.1 membrane protein -
DK237_RS09940 1983286..1984194 - 909 WP_074411269.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
DK237_RS09945 1984178..1984708 - 531 WP_009910909.1 DUF1697 domain-containing protein -
DK237_RS09950 1984722..1984979 - 258 WP_013730620.1 Txe/YoeB family addiction module toxin Toxin
DK237_RS09955 1984981..1985241 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DK237_RS09960 1985317..1985772 - 456 WP_013730621.1 8-oxo-dGTP diphosphatase -
DK237_RS09965 1985776..1986144 - 369 WP_013730622.1 hypothetical protein -
DK237_RS09970 1986137..1986706 - 570 WP_022540720.1 ribonuclease M5 -
DK237_RS09975 1986690..1987472 - 783 WP_002939015.1 TatD family hydrolase -
DK237_RS09980 1987580..1987717 - 138 WP_002939016.1 50S ribosomal protein L34 -
DK237_RS09985 1987885..1988880 - 996 WP_013730624.1 protein jag -
DK237_RS09990 1988900..1989712 - 813 WP_004194552.1 YidC/Oxa1 family membrane protein insertase -
DK237_RS09995 1989696..1990055 - 360 WP_013730625.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.86 Da        Isoelectric Point: 8.0279

>T109153 WP_013730620.1 NZ_CP031377:c1984979-1984722 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

>T109153 NZ_CP031377:c1984979-1984722 [Streptococcus suis]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCAAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT109153 WP_002939010.1 NZ_CP031377:c1985241-1984981 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT109153 NZ_CP031377:c1985241-1984981 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E7Z7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References