Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1296255..1296852 Replicon chromosome
Accession NZ_CP031336
Organism Neisseria meningitidis strain M21717

Toxin (Protein)


Gene name higB Uniprot ID A0A0Y6JZK6
Locus tag DV160_RS07870 Protein ID WP_002242826.1
Coordinates 1296574..1296852 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DV160_RS07865 Protein ID WP_002221020.1
Coordinates 1296255..1296566 (-) Length 104 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV160_RS07835 1292098..1292262 + 165 WP_002224559.1 baseplate J/gp47 family protein -
DV160_RS07840 1292262..1292873 + 612 WP_002224558.1 baseplate J/gp47 family protein -
DV160_RS07845 1292870..1293430 + 561 WP_002213590.1 YmfQ family protein -
DV160_RS07850 1293441..1295414 + 1974 WP_002221022.1 pyocin knob domain-containing protein -
DV160_RS07865 1296255..1296566 - 312 WP_002221020.1 HigA family addiction module antidote protein Antitoxin
DV160_RS07870 1296574..1296852 - 279 WP_002242826.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DV160_RS07875 1296937..1297542 + 606 WP_002219301.1 hypothetical protein -
DV160_RS07880 1297521..1297817 + 297 WP_002221017.1 hypothetical protein -
DV160_RS07885 1297814..1298023 + 210 WP_002221016.1 hypothetical protein -
DV160_RS07890 1298133..1299275 - 1143 WP_002221015.1 ABC transporter ATP-binding protein/permease -
DV160_RS07900 1299717..1300364 - 648 WP_002217218.1 DUF799 domain-containing protein -
DV160_RS07905 1300361..1300729 - 369 WP_002219297.1 DUF4810 domain-containing protein -
DV160_RS07910 1300739..1301410 - 672 WP_002217215.1 CsgG/HfaB family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1284216..1297817 13601
- flank IS/Tn - - 1291068..1292033 965


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-92)

Antitoxin

(3-80)


Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10237.66 Da        Isoelectric Point: 10.0980

>T108936 WP_002242826.1 NZ_CP031336:c1296852-1296574 [Neisseria meningitidis]
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH

Download         Length: 279 bp

>T108936 NZ_CP031336:c1296852-1296574 [Neisseria meningitidis]
ATGATTGTTTCTTTCAAACACAAAGGGCTTGAACGCTTTTTTAAAACAGGCTCGCTATCGGGCATCCAAGCCGGGCATTC
CGTCAAACTGAATCTGCTTCTAACCGCGCTGAATGCCGCGCAAACGCCTTCGGATATGGCTGTGCCGAGTTGGAATCTTC
ATCCCCTCAAGGGCAGTTTGTCGGGACATTGGGCGGTTAAAGTCAACGGAAATTGGCGTTTGACTTTTCGTTTCAACGAC
GGCAATGCCGAAGTTGTCGATTATCAGGATTATCACTAG

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11476.32 Da        Isoelectric Point: 10.5523

>AT108936 WP_002221020.1 NZ_CP031336:c1296566-1296255 [Neisseria meningitidis]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA

Download         Length: 312 bp

>AT108936 NZ_CP031336:c1296566-1296255 [Neisseria meningitidis]
ATGAAAATGCACAATCCTGCCCACCCGGGCCTTGTTTTAAAAGAGTATATTAACGGTGCAAGCATTACCGATATAGCGAA
ACGCCTGGGTGTCAGCCGGGTTGCCTTATCGCGCATTGTCAACGCCCAATCTTCGATTACGCCCGAGATGGCGGTTCGTT
TAAGCCAACTGCTCAATACTTCGCCTGATTTTTGGCTGAATATGCAGGCCGGTTATGATTTGTGGCAAATCAGGCAACGC
AAAACTTTTGATATTGCGCCCTTATTTCCCGAACCGCCTTTGTCTTCGATGCAAACAGGTGCAAGGGCTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0Y6JZK6


Antitoxin

Source ID Structure

References