Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 1296255..1296852 | Replicon | chromosome |
Accession | NZ_CP031336 | ||
Organism | Neisseria meningitidis strain M21717 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A0Y6JZK6 |
Locus tag | DV160_RS07870 | Protein ID | WP_002242826.1 |
Coordinates | 1296574..1296852 (-) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | DV160_RS07865 | Protein ID | WP_002221020.1 |
Coordinates | 1296255..1296566 (-) | Length | 104 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DV160_RS07835 | 1292098..1292262 | + | 165 | WP_002224559.1 | baseplate J/gp47 family protein | - |
DV160_RS07840 | 1292262..1292873 | + | 612 | WP_002224558.1 | baseplate J/gp47 family protein | - |
DV160_RS07845 | 1292870..1293430 | + | 561 | WP_002213590.1 | YmfQ family protein | - |
DV160_RS07850 | 1293441..1295414 | + | 1974 | WP_002221022.1 | pyocin knob domain-containing protein | - |
DV160_RS07865 | 1296255..1296566 | - | 312 | WP_002221020.1 | HigA family addiction module antidote protein | Antitoxin |
DV160_RS07870 | 1296574..1296852 | - | 279 | WP_002242826.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
DV160_RS07875 | 1296937..1297542 | + | 606 | WP_002219301.1 | hypothetical protein | - |
DV160_RS07880 | 1297521..1297817 | + | 297 | WP_002221017.1 | hypothetical protein | - |
DV160_RS07885 | 1297814..1298023 | + | 210 | WP_002221016.1 | hypothetical protein | - |
DV160_RS07890 | 1298133..1299275 | - | 1143 | WP_002221015.1 | ABC transporter ATP-binding protein/permease | - |
DV160_RS07900 | 1299717..1300364 | - | 648 | WP_002217218.1 | DUF799 domain-containing protein | - |
DV160_RS07905 | 1300361..1300729 | - | 369 | WP_002219297.1 | DUF4810 domain-containing protein | - |
DV160_RS07910 | 1300739..1301410 | - | 672 | WP_002217215.1 | CsgG/HfaB family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 1284216..1297817 | 13601 | |
- | flank | IS/Tn | - | - | 1291068..1292033 | 965 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10237.66 Da Isoelectric Point: 10.0980
>T108936 WP_002242826.1 NZ_CP031336:c1296852-1296574 [Neisseria meningitidis]
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH
Download Length: 279 bp
>T108936 NZ_CP031336:c1296852-1296574 [Neisseria meningitidis]
ATGATTGTTTCTTTCAAACACAAAGGGCTTGAACGCTTTTTTAAAACAGGCTCGCTATCGGGCATCCAAGCCGGGCATTC
CGTCAAACTGAATCTGCTTCTAACCGCGCTGAATGCCGCGCAAACGCCTTCGGATATGGCTGTGCCGAGTTGGAATCTTC
ATCCCCTCAAGGGCAGTTTGTCGGGACATTGGGCGGTTAAAGTCAACGGAAATTGGCGTTTGACTTTTCGTTTCAACGAC
GGCAATGCCGAAGTTGTCGATTATCAGGATTATCACTAG
ATGATTGTTTCTTTCAAACACAAAGGGCTTGAACGCTTTTTTAAAACAGGCTCGCTATCGGGCATCCAAGCCGGGCATTC
CGTCAAACTGAATCTGCTTCTAACCGCGCTGAATGCCGCGCAAACGCCTTCGGATATGGCTGTGCCGAGTTGGAATCTTC
ATCCCCTCAAGGGCAGTTTGTCGGGACATTGGGCGGTTAAAGTCAACGGAAATTGGCGTTTGACTTTTCGTTTCAACGAC
GGCAATGCCGAAGTTGTCGATTATCAGGATTATCACTAG
Antitoxin
Download Length: 104 a.a. Molecular weight: 11476.32 Da Isoelectric Point: 10.5523
>AT108936 WP_002221020.1 NZ_CP031336:c1296566-1296255 [Neisseria meningitidis]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA
Download Length: 312 bp
>AT108936 NZ_CP031336:c1296566-1296255 [Neisseria meningitidis]
ATGAAAATGCACAATCCTGCCCACCCGGGCCTTGTTTTAAAAGAGTATATTAACGGTGCAAGCATTACCGATATAGCGAA
ACGCCTGGGTGTCAGCCGGGTTGCCTTATCGCGCATTGTCAACGCCCAATCTTCGATTACGCCCGAGATGGCGGTTCGTT
TAAGCCAACTGCTCAATACTTCGCCTGATTTTTGGCTGAATATGCAGGCCGGTTATGATTTGTGGCAAATCAGGCAACGC
AAAACTTTTGATATTGCGCCCTTATTTCCCGAACCGCCTTTGTCTTCGATGCAAACAGGTGCAAGGGCTTAA
ATGAAAATGCACAATCCTGCCCACCCGGGCCTTGTTTTAAAAGAGTATATTAACGGTGCAAGCATTACCGATATAGCGAA
ACGCCTGGGTGTCAGCCGGGTTGCCTTATCGCGCATTGTCAACGCCCAATCTTCGATTACGCCCGAGATGGCGGTTCGTT
TAAGCCAACTGCTCAATACTTCGCCTGATTTTTGGCTGAATATGCAGGCCGGTTATGATTTGTGGCAAATCAGGCAACGC
AAAACTTTTGATATTGCGCCCTTATTTCCCGAACCGCCTTTGTCTTCGATGCAAACAGGTGCAAGGGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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