Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1768081..1768678 Replicon chromosome
Accession NZ_CP031335
Organism Neisseria meningitidis strain M25964

Toxin (Protein)


Gene name higB Uniprot ID A0A0Y6JZK6
Locus tag DV178_RS10570 Protein ID WP_002242826.1
Coordinates 1768400..1768678 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DV178_RS10565 Protein ID WP_002221020.1
Coordinates 1768081..1768392 (-) Length 104 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV178_RS10535 1763913..1764077 + 165 WP_002224559.1 baseplate J/gp47 family protein -
DV178_RS10540 1764077..1764688 + 612 WP_002224558.1 baseplate J/gp47 family protein -
DV178_RS10545 1764685..1765245 + 561 WP_002213590.1 YmfQ family protein -
DV178_RS10550 1765256..1767229 + 1974 WP_063399752.1 pyocin knob domain-containing protein -
DV178_RS10565 1768081..1768392 - 312 WP_002221020.1 HigA family addiction module antidote protein Antitoxin
DV178_RS10570 1768400..1768678 - 279 WP_002242826.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DV178_RS10575 1768763..1769368 + 606 WP_061370312.1 hypothetical protein -
DV178_RS10580 1769347..1769643 + 297 WP_002221017.1 hypothetical protein -
DV178_RS10585 1769640..1769849 + 210 WP_002222487.1 hypothetical protein -
DV178_RS10590 1769959..1771102 - 1144 Protein_1714 ABC transporter ATP-binding protein/permease -
DV178_RS10600 1771544..1772191 - 648 WP_002217218.1 DUF799 domain-containing protein -
DV178_RS10605 1772188..1772556 - 369 WP_002219297.1 DUF4810 domain-containing protein -
DV178_RS10610 1772566..1773237 - 672 WP_002217215.1 CsgG/HfaB family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1753686..1769643 15957
- flank IS/Tn - - 1762883..1763848 965


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-92)

Antitoxin

(3-80)


Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10237.66 Da        Isoelectric Point: 10.0980

>T108935 WP_002242826.1 NZ_CP031335:c1768678-1768400 [Neisseria meningitidis]
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH

Download         Length: 279 bp

>T108935 NZ_CP031335:c1768678-1768400 [Neisseria meningitidis]
ATGATTGTTTCTTTCAAACACAAAGGGCTTGAACGCTTTTTTAAAACAGGCTCGCTATCGGGCATCCAAGCTGGGCATTC
CGTCAAACTGAATCTGCTTCTAACCGCGCTGAATGCCGCGCAAACGCCTTCGGATATGGCTGTGCCGAGTTGGAATCTTC
ATCCCCTCAAGGGCAGTTTGTCGGGACATTGGGCGGTTAAAGTCAACGGAAATTGGCGTTTGACTTTTCGTTTCAACGAC
GGCAATGCCGAAGTTGTCGATTATCAGGATTATCACTAG

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11476.32 Da        Isoelectric Point: 10.5523

>AT108935 WP_002221020.1 NZ_CP031335:c1768392-1768081 [Neisseria meningitidis]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA

Download         Length: 312 bp

>AT108935 NZ_CP031335:c1768392-1768081 [Neisseria meningitidis]
ATGAAAATGCACAATCCTGCCCACCCGGGCCTTGTTTTAAAAGAGTATATTAACGGTGCAAGCATTACCGATATAGCGAA
ACGCCTGGGTGTCAGCCGGGTTGCCTTATCGCGCATTGTCAACGCCCAATCTTCGATTACGCCCGAGATGGCGGTTCGTT
TAAGCCAACTGCTCAATACTTCGCCTGATTTTTGGCTGAATATGCAGGCCGGTTATGATTTGTGGCAAATCAGGCAACGC
AAAACTTTTGATATTGCGCCCTTATTTCCCGAACCGCCTTTGTCTTCGATGCAAACAGGTGCAAGGGCTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0Y6JZK6


Antitoxin

Source ID Structure

References