Detailed information of TA system
Overview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 1768081..1768678 | Replicon | chromosome |
Accession | NZ_CP031335 | ||
Organism | Neisseria meningitidis strain M25964 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A0Y6JZK6 |
Locus tag | DV178_RS10570 | Protein ID | WP_002242826.1 |
Coordinates | 1768400..1768678 (-) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | DV178_RS10565 | Protein ID | WP_002221020.1 |
Coordinates | 1768081..1768392 (-) | Length | 104 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DV178_RS10535 | 1763913..1764077 | + | 165 | WP_002224559.1 | baseplate J/gp47 family protein | - |
DV178_RS10540 | 1764077..1764688 | + | 612 | WP_002224558.1 | baseplate J/gp47 family protein | - |
DV178_RS10545 | 1764685..1765245 | + | 561 | WP_002213590.1 | YmfQ family protein | - |
DV178_RS10550 | 1765256..1767229 | + | 1974 | WP_063399752.1 | pyocin knob domain-containing protein | - |
DV178_RS10565 | 1768081..1768392 | - | 312 | WP_002221020.1 | HigA family addiction module antidote protein | Antitoxin |
DV178_RS10570 | 1768400..1768678 | - | 279 | WP_002242826.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
DV178_RS10575 | 1768763..1769368 | + | 606 | WP_061370312.1 | hypothetical protein | - |
DV178_RS10580 | 1769347..1769643 | + | 297 | WP_002221017.1 | hypothetical protein | - |
DV178_RS10585 | 1769640..1769849 | + | 210 | WP_002222487.1 | hypothetical protein | - |
DV178_RS10590 | 1769959..1771102 | - | 1144 | Protein_1714 | ABC transporter ATP-binding protein/permease | - |
DV178_RS10600 | 1771544..1772191 | - | 648 | WP_002217218.1 | DUF799 domain-containing protein | - |
DV178_RS10605 | 1772188..1772556 | - | 369 | WP_002219297.1 | DUF4810 domain-containing protein | - |
DV178_RS10610 | 1772566..1773237 | - | 672 | WP_002217215.1 | CsgG/HfaB family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 1753686..1769643 | 15957 | |
- | flank | IS/Tn | - | - | 1762883..1763848 | 965 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10237.66 Da Isoelectric Point: 10.0980
>T108935 WP_002242826.1 NZ_CP031335:c1768678-1768400 [Neisseria meningitidis]
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH
Download Length: 279 bp
>T108935 NZ_CP031335:c1768678-1768400 [Neisseria meningitidis]
ATGATTGTTTCTTTCAAACACAAAGGGCTTGAACGCTTTTTTAAAACAGGCTCGCTATCGGGCATCCAAGCTGGGCATTC
CGTCAAACTGAATCTGCTTCTAACCGCGCTGAATGCCGCGCAAACGCCTTCGGATATGGCTGTGCCGAGTTGGAATCTTC
ATCCCCTCAAGGGCAGTTTGTCGGGACATTGGGCGGTTAAAGTCAACGGAAATTGGCGTTTGACTTTTCGTTTCAACGAC
GGCAATGCCGAAGTTGTCGATTATCAGGATTATCACTAG
ATGATTGTTTCTTTCAAACACAAAGGGCTTGAACGCTTTTTTAAAACAGGCTCGCTATCGGGCATCCAAGCTGGGCATTC
CGTCAAACTGAATCTGCTTCTAACCGCGCTGAATGCCGCGCAAACGCCTTCGGATATGGCTGTGCCGAGTTGGAATCTTC
ATCCCCTCAAGGGCAGTTTGTCGGGACATTGGGCGGTTAAAGTCAACGGAAATTGGCGTTTGACTTTTCGTTTCAACGAC
GGCAATGCCGAAGTTGTCGATTATCAGGATTATCACTAG
Antitoxin
Download Length: 104 a.a. Molecular weight: 11476.32 Da Isoelectric Point: 10.5523
>AT108935 WP_002221020.1 NZ_CP031335:c1768392-1768081 [Neisseria meningitidis]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA
Download Length: 312 bp
>AT108935 NZ_CP031335:c1768392-1768081 [Neisseria meningitidis]
ATGAAAATGCACAATCCTGCCCACCCGGGCCTTGTTTTAAAAGAGTATATTAACGGTGCAAGCATTACCGATATAGCGAA
ACGCCTGGGTGTCAGCCGGGTTGCCTTATCGCGCATTGTCAACGCCCAATCTTCGATTACGCCCGAGATGGCGGTTCGTT
TAAGCCAACTGCTCAATACTTCGCCTGATTTTTGGCTGAATATGCAGGCCGGTTATGATTTGTGGCAAATCAGGCAACGC
AAAACTTTTGATATTGCGCCCTTATTTCCCGAACCGCCTTTGTCTTCGATGCAAACAGGTGCAAGGGCTTAA
ATGAAAATGCACAATCCTGCCCACCCGGGCCTTGTTTTAAAAGAGTATATTAACGGTGCAAGCATTACCGATATAGCGAA
ACGCCTGGGTGTCAGCCGGGTTGCCTTATCGCGCATTGTCAACGCCCAATCTTCGATTACGCCCGAGATGGCGGTTCGTT
TAAGCCAACTGCTCAATACTTCGCCTGATTTTTGGCTGAATATGCAGGCCGGTTATGATTTGTGGCAAATCAGGCAACGC
AAAACTTTTGATATTGCGCCCTTATTTCCCGAACCGCCTTTGTCTTCGATGCAAACAGGTGCAAGGGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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