Detailed information of TA system TA108934

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 788754..789351
• Replicon: chromosome
• Accession: NZ_CP031331
• Organism: Neisseria meningitidis strain M26263

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0Y6JZK6
• Locus tag: DV179_RS04640
• Protein ID: WP_002242826.1
• Coordinates: 788754..789032 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DV179_RS04645
• Protein ID: WP_002221020.1
• Coordinates: 789040..789351 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV179_RS04600	784196..784867	+	672	WP_002217215.1	CsgG/HfaB family protein	-
DV179_RS04605	784877..785245	+	369	WP_002219297.1	DUF4810 domain-containing protein	-
DV179_RS04610	785242..785889	+	648	WP_002217218.1	DUF799 domain-containing protein	-
DV179_RS04620	786331..787473	+	1143	WP_002221015.1	ABC transporter ATP-binding protein/permease	-
DV179_RS04625	787583..787792	-	210	WP_002221016.1	hypothetical protein	-
DV179_RS04630	787789..788085	-	297	WP_002221017.1	hypothetical protein	-
DV179_RS04635	788064..788669	-	606	WP_002219301.1	hypothetical protein	-
DV179_RS04640	788754..789032	+	279	WP_002242826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DV179_RS04645	789040..789351	+	312	WP_002221020.1	HigA family addiction module antidote protein	Antitoxin
DV179_RS04655	789969..791942	-	1974	WP_002221022.1	pyocin knob domain-containing protein	-
DV179_RS04660	791953..792513	-	561	WP_002213590.1	YmfQ family protein	-
DV179_RS04665	792510..793121	-	612	WP_002224558.1	baseplate J/gp47 family protein	-
DV179_RS04670	793121..793285	-	165	WP_002224559.1	baseplate J/gp47 family protein	-
DV179_RS04675	793350..794315	+	966	WP_002221064.1	IS30-like element IS1655 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	787789..803530	15741
	-	flank	IS/Tn	-	-	793350..794315	965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-80)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10237.66 Da
• Isoelectric Point: 10.0980

>T108934 WP_002242826.1 NZ_CP031331:788754-789032 [Neisseria meningitidis]
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH

Nucleotide

• Length: 279 bp

>T108934 NZ_CP031331:788754-789032 [Neisseria meningitidis]
ATGATTGTTTCTTTCAAACACAAAGGGCTTGAACGCTTTTTTAAAACAGGCTCGCTATCGGGCATCCAAGCCGGGCATTC
CGTCAAACTGAATCTGCTTCTAACCGCGCTGAATGCCGCGCAAACGCCTTCGGATATGGCTGTGCCGAGTTGGAATCTTC
ATCCCCTCAAGGGCAGTTTGTCGGGACATTGGGCGGTTAAAGTCAACGGAAATTGGCGTTTGACTTTTCGTTTCAACGAC
GGCAATGCCGAAGTTGTCGATTATCAGGATTATCACTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11476.32 Da
• Isoelectric Point: 10.5523

>AT108934 WP_002221020.1 NZ_CP031331:789040-789351 [Neisseria meningitidis]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA

Nucleotide

• Length: 312 bp

>AT108934 NZ_CP031331:789040-789351 [Neisseria meningitidis]
ATGAAAATGCACAATCCTGCCCACCCGGGCCTTGTTTTAAAAGAGTATATTAACGGTGCAAGCATTACCGATATAGCGAA
ACGCCTGGGTGTCAGCCGGGTTGCCTTATCGCGCATTGTCAACGCCCAATCTTCGATTACGCCCGAGATGGCGGTTCGTT
TAAGCCAACTGCTCAATACTTCGCCTGATTTTTGGCTGAATATGCAGGCCGGTTATGATTTGTGGCAAATCAGGCAACGC
AAAACTTTTGATATTGCGCCCTTATTTCCCGAACCGCCTTTGTCTTCGATGCAAACAGGTGCAAGGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Y6JZK6