Detailed information of TA system TA108933

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2070951..2071548
• Replicon: chromosome
• Accession: NZ_CP031326
• Organism: Neisseria meningitidis strain M21374

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0Y6JZK6
• Locus tag: DV155_RS12315
• Protein ID: WP_002242826.1
• Coordinates: 2071270..2071548 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DV155_RS12310
• Protein ID: WP_002221020.1
• Coordinates: 2070951..2071262 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV155_RS12280	2066818..2066982	+	165	WP_002224559.1	baseplate J/gp47 family protein	-
DV155_RS12285	2066982..2067593	+	612	WP_002224558.1	baseplate J/gp47 family protein	-
DV155_RS12290	2067590..2068150	+	561	WP_002213590.1	YmfQ family protein	-
DV155_RS12295	2068161..2070134	+	1974	WP_002221022.1	pyocin knob domain-containing protein	-
DV155_RS12310	2070951..2071262	-	312	WP_002221020.1	HigA family addiction module antidote protein	Antitoxin
DV155_RS12315	2071270..2071548	-	279	WP_002242826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DV155_RS12320	2071633..2072238	+	606	WP_002219301.1	hypothetical protein	-
DV155_RS12325	2072217..2072513	+	297	WP_002221017.1	hypothetical protein	-
DV155_RS12330	2072510..2072719	+	210	WP_002221016.1	hypothetical protein	-
DV155_RS12335	2072829..2073971	-	1143	WP_002221015.1	ABC transporter ATP-binding protein/permease	-
DV155_RS12345	2074413..2075060	-	648	WP_002217218.1	DUF799 domain-containing protein	-
DV155_RS12350	2075057..2075425	-	369	WP_002219297.1	DUF4810 domain-containing protein	-
DV155_RS12355	2075435..2076106	-	672	WP_002217215.1	CsgG/HfaB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2056393..2072513	16120
	-	flank	IS/Tn	-	-	2065788..2066753	965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-80)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10237.66 Da
• Isoelectric Point: 10.0980

>T108933 WP_002242826.1 NZ_CP031326:c2071548-2071270 [Neisseria meningitidis]
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH

Nucleotide

• Length: 279 bp

>T108933 NZ_CP031326:c2071548-2071270 [Neisseria meningitidis]
ATGATTGTTTCTTTCAAACACAAAGGGCTTGAACGCTTTTTTAAAACAGGCTCGCTATCGGGCATCCAAGCCGGGCATTC
CGTCAAACTGAATCTGCTTCTAACCGCGCTGAATGCCGCGCAAACGCCTTCGGATATGGCTGTGCCGAGTTGGAATCTTC
ATCCCCTCAAGGGCAGTTTGTCGGGACATTGGGCGGTTAAAGTCAACGGAAATTGGCGTTTGACTTTTCGTTTCAACGAC
GGCAATGCCGAAGTTGTCGATTATCAGGATTATCACTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11476.32 Da
• Isoelectric Point: 10.5523

>AT108933 WP_002221020.1 NZ_CP031326:c2071262-2070951 [Neisseria meningitidis]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA

Nucleotide

• Length: 312 bp

>AT108933 NZ_CP031326:c2071262-2070951 [Neisseria meningitidis]
ATGAAAATGCACAATCCTGCCCACCCGGGCCTTGTTTTAAAAGAGTATATTAACGGTGCAAGCATTACCGATATAGCGAA
ACGCCTGGGTGTCAGCCGGGTTGCCTTATCGCGCATTGTCAACGCCCAATCTTCGATTACGCCCGAGATGGCGGTTCGTT
TAAGCCAACTGCTCAATACTTCGCCTGATTTTTGGCTGAATATGCAGGCCGGTTATGATTTGTGGCAAATCAGGCAACGC
AAAACTTTTGATATTGCGCCCTTATTTCCCGAACCGCCTTTGTCTTCGATGCAAACAGGTGCAAGGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Y6JZK6