Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2008579..2009179 Replicon chromosome
Accession NZ_CP031324
Organism Neisseria meningitidis strain M23347

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DV175_RS11755 Protein ID WP_196958325.1
Coordinates 2008898..2009179 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DV175_RS11750 Protein ID WP_002221020.1
Coordinates 2008579..2008890 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV175_RS11720 2004028..2004354 + 327 WP_002238081.1 GPW/gp25 family protein -
DV175_RS11725 2004375..2005262 + 888 WP_002238082.1 baseplate J/gp47 family protein -
DV175_RS11730 2005262..2005840 + 579 WP_115437426.1 phage tail protein I -
DV175_RS11735 2005881..2008121 + 2241 WP_115437409.1 pyocin knob domain-containing protein -
DV175_RS11750 2008579..2008890 - 312 WP_002221020.1 HigA family addiction module antidote protein Antitoxin
DV175_RS11755 2008898..2009179 - 282 WP_196958325.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DV175_RS11760 2009261..2009866 + 606 WP_002223791.1 hypothetical protein -
DV175_RS11765 2009845..2010141 + 297 WP_002242836.1 hypothetical protein -
DV175_RS14210 2010138..2010305 + 168 WP_002238087.1 hypothetical protein -
DV175_RS11770 2010368..2011555 + 1188 WP_002238088.1 phage tail sheath subtilisin-like domain-containing protein -
DV175_RS11775 2011598..2012104 + 507 WP_002238089.1 phage major tail tube protein -
DV175_RS11780 2012151..2012510 + 360 WP_002238090.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1995951..2028319 32368


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-80)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10369.79 Da        Isoelectric Point: 8.6441

>T108932 WP_196958325.1 NZ_CP031324:c2009179-2008898 [Neisseria meningitidis]
MMIVSFKHKGLERFFKTGSLSGIQAGHSVELNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFN
DGNAEVVDYQDYH

Download         Length: 282 bp

>T108932 NZ_CP031324:c2009179-2008898 [Neisseria meningitidis]
ATGATGATTGTTTCTTTCAAACACAAAGGGCTTGAACGCTTTTTTAAAACAGGCTCGCTATCGGGCATCCAAGCTGGGCA
TTCCGTCGAACTGAATCTGCTTCTAACCGCGCTGAATGCCGCGCAAACGCCTTCGGATATGGCTGTGCCGAGTTGGAATC
TTCATCCCCTCAAGGGCAGTTTGTCGGGACATTGGGCGGTTAAAGTCAACGGAAATTGGCGTTTGACTTTTCGTTTCAAC
GACGGCAATGCCGAAGTTGTCGATTATCAGGATTATCACTAG

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11476.32 Da        Isoelectric Point: 10.5523

>AT108932 WP_002221020.1 NZ_CP031324:c2008890-2008579 [Neisseria meningitidis]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA

Download         Length: 312 bp

>AT108932 NZ_CP031324:c2008890-2008579 [Neisseria meningitidis]
ATGAAAATGCACAATCCTGCCCACCCGGGCCTTGTTTTAAAAGAGTATATTAACGGTGCAAGCATTACCGATATAGCGAA
ACGCCTGGGTGTCAGCCGGGTTGCCTTATCGCGCATTGTCAACGCCCAATCTTCGATTACGCCCGAGATGGCGGTTCGTT
TAAGCCAACTGCTCAATACTTCGCCTGATTTTTGGCTGAATATGCAGGCCGGTTATGATTTGTGGCAAATCAGGCAACGC
AAAACTTTTGATATTGCGCCCTTATTTCCCGAACCGCCTTTGTCTTCGATGCAAACAGGTGCAAGGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References