Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4426323..4426951 Replicon chromosome
Accession NZ_CP031316
Organism Serratia marcescens strain N4-5

Toxin (Protein)


Gene name higB Uniprot ID A0A8G2G488
Locus tag Smn45_RS21250 Protein ID WP_016930174.1
Coordinates 4426323..4426613 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Smn45_RS21255 Protein ID WP_016930175.1
Coordinates 4426628..4426951 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Smn45_RS21240 4422737..4424758 + 2022 WP_115436546.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
Smn45_RS21245 4424953..4426092 - 1140 WP_016930173.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
Smn45_RS21250 4426323..4426613 + 291 WP_016930174.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Smn45_RS21255 4426628..4426951 + 324 WP_016930175.1 HigA family addiction module antidote protein Antitoxin
Smn45_RS21260 4426944..4427456 + 513 WP_016930176.1 M48 family metallopeptidase -
Smn45_RS21265 4427506..4428486 + 981 WP_016930177.1 Gfo/Idh/MocA family oxidoreductase -
Smn45_RS21270 4428488..4429219 + 732 WP_016930178.1 glutamine amidotransferase -
Smn45_RS21275 4429475..4430440 + 966 WP_028127587.1 TerC family protein -
Smn45_RS21280 4430703..4431938 + 1236 WP_049299890.1 serine/threonine transporter SstT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-71)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11645.30 Da        Isoelectric Point: 10.2782

>T108901 WP_016930174.1 NZ_CP031316:4426323-4426613 [Serratia marcescens]
MIKSFRDRYLEQFYLEGRRSRLIPGALERQLARKLDMLAAAQQERDLHHPTGNYYKRLSGPFQGWSSLRVNMHWRLMFQW
RHDAAEKIYLDPHQDT

Download         Length: 291 bp

>T108901 NZ_CP031316:4426323-4426613 [Serratia marcescens]
ATGATTAAATCTTTCCGCGATCGCTATCTGGAGCAGTTCTATCTGGAAGGCAGGCGCAGCCGTCTGATCCCCGGCGCGCT
TGAGCGACAGTTGGCCAGAAAACTCGATATGTTGGCCGCCGCGCAGCAAGAGCGTGATTTGCATCACCCCACGGGTAACT
ATTACAAGCGGCTATCCGGACCATTTCAGGGATGGTCAAGTCTGCGCGTCAATATGCACTGGCGGCTGATGTTCCAGTGG
CGGCATGATGCCGCTGAAAAAATTTACCTCGATCCTCATCAAGATACCTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12240.92 Da        Isoelectric Point: 6.7208

>AT108901 WP_016930175.1 NZ_CP031316:4426628-4426951 [Serratia marcescens]
MLETTTREPTTVGEVLQEEYLTPLGIGQEELAKVLGVTRATVNRLCNGHRRMSVAEANLFADLFETTADFWLNLQAAHDR
WEARQADAQRVRLRPIKEILRRNITHA

Download         Length: 324 bp

>AT108901 NZ_CP031316:4426628-4426951 [Serratia marcescens]
ATGTTGGAAACCACGACTCGCGAACCCACCACGGTGGGAGAAGTGCTGCAGGAAGAATATTTAACACCGCTAGGCATCGG
CCAGGAGGAACTGGCAAAGGTATTGGGCGTCACCCGCGCCACCGTCAATCGCCTGTGCAACGGGCATCGACGCATGAGCG
TTGCCGAGGCCAATCTGTTTGCCGATCTGTTCGAAACGACCGCTGACTTTTGGCTAAACCTGCAGGCGGCGCACGATCGC
TGGGAAGCCAGACAGGCCGATGCGCAGCGTGTGCGGTTGCGGCCGATCAAAGAAATACTGAGGCGCAATATCACTCATGC
ATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References