Detailed information of TA system TA108834

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2474737..2475392
• Replicon: chromosome
• Accession: NZ_CP031289
• Organism: Bordetella pertussis strain UK36

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: DVA61_RS11795
• Protein ID: WP_047122780.1
• Coordinates: 2475141..2475392 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: DVA61_RS11790
• Protein ID: WP_003809516.1
• Coordinates: 2474737..2475138 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DVA61_RS11760 (DVA61_11870)	2469920..2470942	-	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-
DVA61_RS11765 (DVA61_11875)	2471079..2472116	-	1038	WP_023853543.1	L-threonylcarbamoyladenylate synthase	-
DVA61_RS11770 (DVA61_11880)	2472136..2473326	-	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
DVA61_RS11775 (DVA61_11885)	2473329..2473844	-	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
DVA61_RS11780 (DVA61_11890)	2473994..2474473	-	480	WP_010930405.1	disulfide bond formation protein B	-
DVA61_RS11785 (DVA61_11895)	2474481..2474639	-	159	WP_023853545.1	DUF5993 family protein	-
DVA61_RS11790 (DVA61_11900)	2474737..2475138	-	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
DVA61_RS11795 (DVA61_11905)	2475141..2475392	-	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
DVA61_RS11800 (DVA61_11910)	2475447..2476328	-	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
DVA61_RS11805 (DVA61_11915)	2476553..2476999	+	447	WP_003819827.1	GFA family protein	-
DVA61_RS11810 (DVA61_11920)	2477084..2478148	-	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
DVA61_RS11815 (DVA61_11925)	2478285..2478866	-	582	WP_019247931.1	MOSC domain-containing protein	-
DVA61_RS11820 (DVA61_11930)	2479101..2480231	+	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T108834 WP_047122780.1 NZ_CP031289:c2475392-2475141 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T108834 NZ_CP031289:c2475392-2475141 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT108834 WP_003809516.1 NZ_CP031289:c2475138-2474737 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT108834 NZ_CP031289:c2475138-2474737 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6