Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2320803..2321284 Replicon chromosome
Accession NZ_CP031289
Organism Bordetella pertussis strain UK36

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DVA61_RS11090 Protein ID WP_225975616.1
Coordinates 2320803..2320982 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DVA61_RS11095 Protein ID WP_019247905.1
Coordinates 2320985..2321284 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DVA61_RS11065 (DVA61_11175) 2316114..2316887 + 774 WP_010930496.1 SDR family NAD(P)-dependent oxidoreductase -
DVA61_RS11070 (DVA61_11180) 2316904..2317926 + 1023 WP_023852774.1 tripartite tricarboxylate transporter substrate binding protein -
DVA61_RS11075 (DVA61_11185) 2318012..2318956 + 945 WP_010930494.1 LysR family transcriptional regulator -
DVA61_RS11080 (DVA61_11190) 2318934..2319803 - 870 WP_010930493.1 TauD/TfdA family dioxygenase -
DVA61_RS11085 (DVA61_11195) 2320047..2320670 + 624 WP_010930492.1 glutathione S-transferase N-terminal domain-containing protein -
DVA61_RS11090 (DVA61_11200) 2320803..2320982 + 180 WP_225975616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DVA61_RS11095 (DVA61_11205) 2320985..2321284 + 300 WP_019247905.1 NadS family protein Antitoxin
DVA61_RS11100 (DVA61_11210) 2321298..2324365 - 3068 Protein_2195 autotransporter SphB2 -
DVA61_RS11105 (DVA61_11215) 2324495..2325169 + 675 WP_010930489.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(5-58)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6859.09 Da        Isoelectric Point: 10.2010

>T108833 WP_225975616.1 NZ_CP031289:2320803-2320982 [Bordetella pertussis]
IRKMHYGRQGTGKRGGIRVIYYWISQDCQIYMLAAYAKSKKINLTPDEIAALRELVKEL

Download         Length: 180 bp

>T108833 NZ_CP031289:2320803-2320982 [Bordetella pertussis]
ATACGAAAGATGCATTACGGCCGGCAAGGCACGGGCAAGCGAGGTGGCATCCGGGTCATTTATTACTGGATCAGCCAGGA
TTGTCAGATCTACATGCTTGCGGCTTATGCAAAGTCGAAGAAGATCAACCTGACCCCGGACGAAATCGCGGCGCTGCGCG
AACTGGTCAAGGAGCTGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10978.76 Da        Isoelectric Point: 11.2467

>AT108833 WP_019247905.1 NZ_CP031289:2320985-2321284 [Bordetella pertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAMA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT108833 NZ_CP031289:2320985-2321284 [Bordetella pertussis]
ATGAAAAAAGACAACACGGTGTTCAACGACCTGCAGGCCAGCCTGAAGCAAGCCGTGGCCATTCGCCAAGGCAAGATGCC
GCCATCGCGTGTATTCAAGGTTGAGACAGTGGATGTGAAGGCAACGCGCGAAAAAACGCACATGTCTCAAACGGAATTCG
CCAAAGCCATCCACGTCAGTGTCCGCACGCTGCAGAACTGGGAGCAAGGGCACCGCAATCCGACGGGCCCTGCCATGGCG
CTTCTGAAAATAGTGGCAAGCGCCCCGGACATTGCCGTGCGAGCGCTGCGGACCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References