Detailed information of TA system TA108802

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2422651..2422835
• Replicon: chromosome
• Accession: NZ_CP031265
• Organism: Staphylococcus aureus strain 13

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: DWB87_RS12355
• Protein ID: WP_000482647.1
• Coordinates: 2422728..2422835 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2422651..2422711 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DWB87_RS12340	2418125..2418292	-	168	WP_001790576.1	hypothetical protein	-
DWB87_RS12345	2418523..2420256	-	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
DWB87_RS12350	2420281..2422044	-	1764	WP_001064816.1	ABC transporter ATP-binding protein/permease	-
-	2422651..2422711	+	61	-	-	Antitoxin
DWB87_RS12355	2422728..2422835	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
DWB87_RS12360	2422969..2423355	-	387	WP_000779360.1	flippase GtxA	-
DWB87_RS12365	2423613..2424755	+	1143	WP_060552761.1	glycerate kinase	-
DWB87_RS12370	2424815..2425474	+	660	WP_000831301.1	membrane protein	-
DWB87_RS12375	2425656..2426867	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
DWB87_RS12380	2426990..2427463	-	474	WP_000456497.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-125)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T108802 WP_000482647.1 NZ_CP031265:c2422835-2422728 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T108802 NZ_CP031265:c2422835-2422728 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT108802 NZ_CP031265:2422651-2422711 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin