Detailed information of TA system TA108791

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF3/-
• Location: 1095215..1095734
• Replicon: chromosome
• Accession: NZ_CP031265
• Organism: Staphylococcus aureus strain 13

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: DWB87_RS05550
• Protein ID: WP_060552602.1
• Coordinates: 1095432..1095734 (+)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1095215..1095352 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DWB87_RS05520	1090482..1094051	+	3570	WP_145392969.1	phage tail protein	-
DWB87_RS05525	1094038..1094190	+	153	WP_060552605.1	hypothetical protein	-
DWB87_RS05530	1094242..1094529	+	288	WP_060552604.1	hypothetical protein	-
DWB87_RS05535	1094586..1094882	+	297	WP_060552603.1	DUF2951 domain-containing protein	-
DWB87_RS05540	1095076..1095223	+	148	Protein_1050	putative holin-like toxin	-
-	1095215..1095352	-	138	NuclAT_0	-	Antitoxin
-	1095215..1095352	-	138	NuclAT_0	-	Antitoxin
-	1095215..1095352	-	138	NuclAT_0	-	Antitoxin
-	1095215..1095352	-	138	NuclAT_0	-	Antitoxin
DWB87_RS05545	1095277..1095381	-	105	Protein_1051	hypothetical protein	-
DWB87_RS05550	1095432..1095734	+	303	WP_060552602.1	phage holin	Toxin
DWB87_RS05555	1095745..1097199	+	1455	WP_060552601.1	N-acetylmuramoyl-L-alanine amidase	-
DWB87_RS05570	1098756..1100693	-	1938	WP_001041586.1	heme uptake protein IsdB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	isdB / isdA / isdC / isdD	1058388..1103916	45528

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (3-68)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11161.88 Da
• Isoelectric Point: 9.6587

>T108791 WP_060552602.1 NZ_CP031265:1095432-1095734 [Staphylococcus aureus]
MEAKVITRYIVLILALVNQFLANKGLSPIPVDEESISSTILTVIALYTTYKDNPTSQEGRWANQKLKKYKAESKYRKATG
QAPIKEVMAPTNMNDTNDLG

Nucleotide

• Length: 303 bp

>T108791 NZ_CP031265:1095432-1095734 [Staphylococcus aureus]
ATGGAAGCAAAAGTAATAACAAGATATATTGTATTAATTTTAGCGTTAGTCAATCAGTTTTTAGCGAACAAAGGTTTAAG
TCCTATTCCAGTTGATGAAGAAAGTATTTCATCGACCATCTTAACAGTTATTGCTTTATACACTACGTATAAAGACAATC
CAACATCACAAGAAGGACGTTGGGCGAATCAAAAATTAAAGAAATATAAAGCTGAAAGTAAATATAGAAAAGCAACAGGT
CAAGCACCTATCAAAGAAGTAATGGCACCTACAAATATGAACGATACAAATGATTTAGGGTAG

Antitoxin

Nucleotide

• Length: 138 bp

>AT108791 NZ_CP031265:c1095352-1095215 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGGATACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTTCTGTCTAATAAT
TAATTATTTAATAAATAATAACCATCGAACCTGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Antitoxin