Detailed information of TA system TA108788

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-couple_hipB
• Location: 2514346..2515022
• Replicon: chromosome
• Accession: NZ_CP031263
• Organism: Micromonospora aurantiaca strain 110B(2018)

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A1C6T5J3
• Locus tag: DVH21_RS12415
• Protein ID: WP_013474046.1
• Coordinates: 2514660..2515022 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DVH21_RS12410
• Protein ID: WP_013284102.1
• Coordinates: 2514346..2514663 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DVH21_RS12370	2509589..2510224	+	636	WP_030271266.1	septum formation initiator family protein	-
DVH21_RS12375	2510248..2510805	+	558	WP_013284095.1	DUF501 domain-containing protein	-
DVH21_RS12380	2510807..2511316	+	510	WP_013284096.1	amino-acid N-acetyltransferase	-
DVH21_RS12385	2511359..2512288	+	930	WP_114919467.1	Ppx/GppA family phosphatase	-
DVH21_RS12390	2512398..2512586	-	189	WP_176921700.1	hypothetical protein	-
DVH21_RS12395	2512675..2512911	+	237	WP_114919468.1	hypothetical protein	-
DVH21_RS12400	2512975..2513307	+	333	WP_030271259.1	PadR family transcriptional regulator	-
DVH21_RS12405	2513304..2514263	+	960	WP_013474045.1	hypothetical protein	-
DVH21_RS12410	2514346..2514663	-	318	WP_013284102.1	helix-turn-helix domain-containing protein	Antitoxin
DVH21_RS12415	2514660..2515022	-	363	WP_013474046.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DVH21_RS12420	2515200..2515967	+	768	WP_114919469.1	dienelactone hydrolase family protein	-
DVH21_RS12425	2515987..2516700	+	714	WP_114919470.1	uracil-DNA glycosylase	-
DVH21_RS12430	2516721..2517452	+	732	WP_013474049.1	DUF4129 domain-containing protein	-
DVH21_RS12435	2517449..2518033	+	585	WP_013284107.1	hypothetical protein	-
DVH21_RS12440	2518033..2519031	+	999	WP_114919471.1	MoxR family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-107)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-87)

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13581.42 Da
• Isoelectric Point: 6.0857

>T108788 WP_013474046.1 NZ_CP031263:c2515022-2514660 [Micromonospora aurantiaca]
VVAGDWDVYLVDEVRQWLDTLDASTHARVVQAIDLLAEHGPGLGRPLVDTIHGSSMANLKELRPGTVRILFAFDPWRSSI
LLVAGDKSGRWKTWYQEAIPVAEHRYELYLKDRAREEGKA

Nucleotide

• Length: 363 bp

>T108788 NZ_CP031263:c2515022-2514660 [Micromonospora aurantiaca]
GTGGTGGCTGGAGACTGGGACGTCTACCTGGTCGACGAGGTGCGGCAGTGGCTCGACACTCTCGACGCGTCCACCCATGC
GCGAGTGGTGCAGGCGATCGACCTCCTGGCCGAGCACGGACCAGGACTCGGACGACCCCTTGTCGACACCATCCACGGTT
CGTCGATGGCGAACTTGAAGGAGCTCCGGCCGGGCACCGTGCGTATCCTTTTCGCGTTCGACCCGTGGCGCTCGAGCATC
CTCCTGGTCGCCGGCGACAAGTCCGGCCGGTGGAAGACGTGGTATCAGGAGGCCATTCCCGTCGCCGAGCACCGCTACGA
GCTCTACCTCAAGGACCGGGCACGAGAGGAGGGGAAGGCATGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11399.80 Da
• Isoelectric Point: 6.7267

>AT108788 WP_013284102.1 NZ_CP031263:c2514663-2514346 [Micromonospora aurantiaca]
MSDYSRWQDIRADHVARVGGEDAVDAGKQELLAEVIGHRLAEVRRARGLTQQQVADRMGVTKGRVSQIEQGKISGQEVVA
RFAAALGGRLHQAIYFDDGDIAAIA

Nucleotide

• Length: 318 bp

>AT108788 NZ_CP031263:c2514663-2514346 [Micromonospora aurantiaca]
ATGAGCGACTACTCCCGGTGGCAGGACATCCGCGCCGACCACGTCGCCCGGGTCGGCGGGGAAGATGCGGTCGACGCGGG
TAAGCAGGAACTCCTCGCCGAGGTCATCGGTCACCGCCTCGCGGAGGTACGGCGAGCGCGCGGCCTGACCCAGCAGCAGG
TCGCCGACCGGATGGGCGTCACCAAGGGACGGGTCTCCCAGATCGAGCAGGGAAAGATCTCCGGACAGGAAGTGGTGGCC
CGGTTCGCCGCGGCGCTGGGTGGCCGGCTCCACCAGGCGATCTACTTCGACGACGGTGACATCGCCGCCATCGCCTGA

Structures

Toxin

• AlphaFold DB: A0A1C6T5J3