Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4744645..4744903 Replicon chromosome
Accession NZ_CP031256
Organism Escherichia coli strain M16807

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag DV447_RS24360 Protein ID WP_000809168.1
Coordinates 4744751..4744903 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4744645..4744702 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV447_RS24340 4740474..4741733 - 1260 WP_000494928.1 hypothetical protein -
DV447_RS24345 4741862..4743355 - 1494 WP_001443162.1 sulfatase-like hydrolase/transferase -
DV447_RS24350 4743375..4744136 - 762 WP_001274832.1 hypothetical protein -
- 4744645..4744702 - 58 - - Antitoxin
DV447_RS24360 4744751..4744903 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
DV447_RS24365 4745008..4746138 - 1131 WP_001118465.1 molecular chaperone DnaJ -
DV447_RS24370 4746227..4748143 - 1917 WP_000516135.1 molecular chaperone DnaK -
DV447_RS24375 4748515..4748919 + 405 WP_000843687.1 DUF2541 family protein -
DV447_RS24380 4748945..4749658 + 714 WP_001102391.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T108763 WP_000809168.1 NZ_CP031256:4744751-4744903 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T108763 NZ_CP031256:4744751-4744903 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT108763 NZ_CP031256:c4744702-4744645 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References