Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4508356..4509154 Replicon chromosome
Accession NZ_CP031256
Organism Escherichia coli strain M16807

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VRA6
Locus tag DV447_RS23210 Protein ID WP_000854730.1
Coordinates 4508777..4509154 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P0SQV8
Locus tag DV447_RS23205 Protein ID WP_001285481.1
Coordinates 4508356..4508730 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV447_RS23165 4504331..4504783 + 453 WP_000682723.1 hypothetical protein -
DV447_RS23170 4504901..4505134 + 234 WP_001213776.1 DUF905 family protein -
DV447_RS23175 4505234..4506055 + 822 WP_001234359.1 DUF945 domain-containing protein -
DV447_RS23180 4506055..4506300 + 246 WP_001164966.1 hypothetical protein -
DV447_RS23185 4506394..4506867 + 474 WP_001313575.1 antirestriction protein -
DV447_RS23190 4506883..4507359 + 477 WP_001313574.1 RadC family protein -
DV447_RS23195 4507422..4507643 + 222 WP_000692315.1 DUF987 domain-containing protein -
DV447_RS23200 4507662..4508306 + 645 WP_000086761.1 hypothetical protein -
DV447_RS23205 4508356..4508730 + 375 WP_001285481.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
DV447_RS23210 4508777..4509154 + 378 WP_000854730.1 TA system toxin CbtA family protein Toxin
DV447_RS23215 4509151..4509643 + 493 Protein_4217 hypothetical protein -
DV447_RS23220 4509722..4510710 - 989 Protein_4218 IS630 family transposase -
DV447_RS23225 4510858..4511046 - 189 Protein_4219 IS66 family transposase -
DV447_RS23230 4511107..4512240 + 1134 WP_000555401.1 IS110-like element ISEc45 family transposase -
DV447_RS23235 4512494..4513898 - 1405 Protein_4221 IS66 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4508356..4518843 10487


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14212.21 Da        Isoelectric Point: 7.2923

>T108761 WP_000854730.1 NZ_CP031256:4508777-4509154 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 378 bp

>T108761 NZ_CP031256:4508777-4509154 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCTTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CAACTACAGAATGGTGAACGACATCATCCGGGGTGAACATTCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13817.53 Da        Isoelectric Point: 4.7511

>AT108761 WP_001285481.1 NZ_CP031256:4508356-4508730 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT108761 NZ_CP031256:4508356-4508730 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCATCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V671

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0SQV8

References