Detailed information of TA system TA108729

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-MqsA
• Location: 1625408..1626060
• Replicon: chromosome
• Accession: NZ_CP031250
• Organism: Haemophilus influenzae strain M21384

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: DV389_RS07940
• Protein ID: WP_114893589.1
• Coordinates: 1625408..1625755 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DV389_RS07945
• Protein ID: WP_048953974.1
• Coordinates: 1625752..1626060 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV389_RS07900	1620827..1621546	+	720	WP_114893688.1	Rha family transcriptional regulator	-
DV389_RS07905	1621712..1622137	+	426	WP_114893584.1	ArsR family transcriptional regulator	-
DV389_RS07915	1623013..1623513	+	501	Protein_1489	host cell division inhibitor Icd-like protein	-
DV389_RS07920	1623557..1623928	+	372	WP_005656483.1	hypothetical protein	-
DV389_RS07925	1623918..1624121	+	204	WP_114893586.1	hypothetical protein	-
DV389_RS07930	1624108..1624824	+	717	WP_114893587.1	hypothetical protein	-
DV389_RS07935	1624817..1625227	+	411	WP_114893588.1	hypothetical protein	-
DV389_RS07940	1625408..1625755	+	348	WP_114893589.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DV389_RS07945	1625752..1626060	+	309	WP_048953974.1	helix-turn-helix domain-containing protein	Antitoxin
DV389_RS07950	1626603..1627631	+	1029	Protein_1496	tyrosine-type recombinase/integrase	-
DV389_RS07960	1628652..1628861	+	210	WP_111691800.1	AlpA family phage regulatory protein	-
DV389_RS07965	1628978..1629208	+	231	WP_050949267.1	transcriptional regulator	-
DV389_RS07970	1629271..1629471	+	201	Protein_1499	helix-turn-helix transcriptional regulator	-
DV389_RS07975	1629490..1629948	+	459	Protein_1500	helix-turn-helix transcriptional regulator	-
DV389_RS07980	1630146..1630797	+	652	Protein_1501	IS1595 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lsgF / lsgE / lsgD	1614030..1640207	26177

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (11-110)

Antitoxin

• Cro/C1-type helix-turn-helix domain (40-80)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13303.07 Da
• Isoelectric Point: 9.2362

>T108729 WP_114893589.1 NZ_CP031250:1625408-1625755 [Haemophilus influenzae]
VKLSFIELPPFERYRKAHLSDDEYRTFQNELLENPEKGDVIQNTGGLRKIRIADSERNEGKRGGARVIYYYFLDGAQIWL
FSAYGKGEKADLNESEKRAFKVVLENLKAMARGKE

Nucleotide

• Length: 348 bp

>T108729 NZ_CP031250:1625408-1625755 [Haemophilus influenzae]
GTGAAACTATCGTTTATTGAATTACCACCCTTTGAGCGTTACAGAAAAGCGCATTTATCTGATGATGAATATCGGACTTT
TCAGAATGAGCTATTAGAAAACCCCGAAAAAGGCGATGTAATACAAAATACAGGCGGATTGAGAAAAATTAGGATTGCAG
ATAGTGAGAGAAATGAAGGGAAACGTGGTGGCGCAAGGGTGATTTATTACTACTTTTTAGACGGTGCGCAAATATGGCTT
TTTAGTGCTTACGGAAAAGGCGAAAAAGCAGACTTAAACGAAAGCGAGAAACGCGCATTTAAAGTGGTATTAGAGAATTT
AAAGGCAATGGCAAGGGGGAAAGAATGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11522.27 Da
• Isoelectric Point: 9.8103

>AT108729 WP_048953974.1 NZ_CP031250:1625752-1626060 [Haemophilus influenzae]
MSRLFDDLMEGAQALEQHLQGKITLRTETRERIEPASITAEEVKAIREKLNLSQAVFAQKLRTSVRTYQGWEQGKTKPSA
HASLLLRMVDKAPQTFELIAGI

Nucleotide

• Length: 309 bp

>AT108729 NZ_CP031250:1625752-1626060 [Haemophilus influenzae]
ATGAGCCGTTTATTTGATGATTTAATGGAAGGCGCGCAAGCTCTTGAGCAACATTTACAAGGTAAAATCACACTACGCAC
AGAAACGCGAGAACGAATTGAGCCAGCAAGCATTACGGCAGAGGAAGTGAAAGCAATTAGAGAGAAATTAAACCTTTCTC
AAGCTGTCTTTGCGCAGAAGTTACGAACCAGTGTAAGAACCTATCAAGGCTGGGAGCAAGGTAAAACCAAACCTAGCGCG
CACGCCTCTTTATTGTTGCGTATGGTGGACAAAGCTCCGCAAACCTTTGAACTTATCGCAGGGATATAA