108723

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 675448..676796 Replicon chromosome
Accession NZ_CP031249
Organism Haemophilus influenzae strain M15895

Toxin (Protein)


Gene name HipT Uniprot ID A0A2S9RZM8
Locus tag DV378_RS03295 Protein ID WP_005692425.1
Coordinates 675765..676796 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID Q4QMQ1
Locus tag DV378_RS03290 Protein ID WP_011272158.1
Coordinates 675448..675768 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV378_RS03245 670692..670970 + 279 WP_050948950.1 cell division protein FtsB -
DV378_RS03250 670970..671647 + 678 WP_050948951.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
DV378_RS03255 671644..672120 + 477 WP_005658971.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
DV378_RS09670 672164..672331 - 168 WP_171970165.1 hypothetical protein -
DV378_RS03265 672597..673031 - 435 WP_005658975.1 D-tyrosyl-tRNA(Tyr) deacylase -
DV378_RS03270 673028..673468 - 441 WP_050948953.1 FMN-binding protein MioC -
DV378_RS03275 673566..673784 - 219 WP_005650820.1 cell division protein ZapB -
DV378_RS03280 673946..674947 + 1002 WP_050948954.1 class II fructose-bisphosphatase -
DV378_RS03285 675152..675460 + 309 WP_050948955.1 helix-turn-helix domain-containing protein -
DV378_RS03290 675448..675768 + 321 WP_011272158.1 type II toxin-antitoxin system HipA family toxin Antitoxin
DV378_RS03295 675765..676796 + 1032 WP_005692425.1 type II toxin-antitoxin system HipA family toxin Toxin
DV378_RS03300 676879..678537 - 1659 WP_050948956.1 thiol reductant ABC exporter subunit CydC -
DV378_RS03305 678530..680275 - 1746 WP_044345224.1 ABC transporter ATP-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39860.42 Da        Isoelectric Point: 6.5050

>T108723 WP_005692425.1 NZ_CP031249:675765-676796 [Haemophilus influenzae]
MNFCRILLKPLKKNEVHSGYSTKGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDDHFDSVDQQ
GHYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNQKEFAFVIKRFDRDEQQKPMHQEQLDGAMNIRDK
YGKIGTDNEQYVSYEQIAKFILQHTENHLAQQQEIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNVLNEPEL

Download         Length: 1032 bp

>T108723 NZ_CP031249:675765-676796 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTGAAGAAAAATGAAGTTCATTCTGGTTACAGCACAAAAGGTTTACACTA
TCTTACAGGCAATAAACATTTTAATCCTGAATTGCCCTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGGATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCAAAGATGATCACTTTGACAGCGTAGATCAACAG
GGACATTACATTTTAAAGCCTTCGCCCGAAGAGTATCCTTTTTTAGCTGAAAATGAACACGCCACCATGCGCATTATGAA
AGAATTAGGGTTTGATGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCAGAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAGCAAAAACCAATGCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TACGGAAAAATAGGTACTGATAATGAGCAATATGTGAGTTATGAACAAATTGCTAAGTTTATTTTACAACACACTGAAAA
TCATTTAGCTCAGCAACAAGAGATTTTCCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAATAGTCATCCAAAACTTGCTCCAATTTATGACTTTGTATCGGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCTTTGCCATTGTTAGCACGAGAAGAGGGTAATGCCACACTCGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATACCTGAAATTACACAAGAAAAGGAAAAGGTGGAGCAGATTTATTCACAATCCTTTATGCCGCAACCACAT
ATTGATTGCGTACTGAAAACTTATCGTAAGCGTTTAGCTTTGCTTAACGTATTAAATGAACCTGAGCTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12437.12 Da        Isoelectric Point: 5.9670

>AT108723 WP_011272158.1 NZ_CP031249:675448-675768 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFAYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
ESDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT108723 NZ_CP031249:675448-675768 [Haemophilus influenzae]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGCGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTGCTTACAATCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGTCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCCCTCGTCCCCGAAGGCTGGCTAAAACACAAATATGCACTTCATCAACGAATTGAT
GAAAGCGATATGTTTCGCTTTTTACTTAATAACGGGGAAAATATGTTAGGTGCAGTGCAAATTCAGGAGGAAAAACAATG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S9RZM8

Antitoxin

Source ID Structure
AlphaFold DB Q4QMQ1

References