Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 38575..39087 Replicon chromosome
Accession NZ_CP031246
Organism Streptococcus pneumoniae strain M26368

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag DV131_RS00205 Protein ID WP_000924721.1
Coordinates 38575..38829 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag DV131_RS00210 Protein ID WP_000388572.1
Coordinates 38833..39087 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV131_RS00190 35676..35990 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
DV131_RS00195 36015..36641 - 627 WP_000775037.1 guanylate kinase -
DV131_RS00200 36771..38384 - 1614 WP_000404940.1 ribonuclease Y -
DV131_RS00205 38575..38829 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
DV131_RS00210 38833..39087 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DV131_RS00215 39325..40422 - 1098 WP_000156356.1 nucleotidyltransferase -
DV131_RS00220 40432..41178 - 747 WP_000605155.1 class I SAM-dependent methyltransferase -
DV131_RS00225 41281..41634 - 354 WP_001003001.1 ribosome silencing factor -
DV131_RS00230 41647..42147 - 501 WP_000844720.1 cysteine hydrolase -
DV131_RS00235 42148..42741 - 594 WP_000121658.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
DV131_RS00240 42741..43370 - 630 WP_000151307.1 nicotinate-nucleotide adenylyltransferase -
DV131_RS00245 43422..43733 - 312 WP_114865802.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T108710 WP_000924721.1 NZ_CP031246:c38829-38575 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T108710 NZ_CP031246:c38829-38575 [Streptococcus pneumoniae]
ATGCTACTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT108710 WP_000388572.1 NZ_CP031246:c39087-38833 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT108710 NZ_CP031246:c39087-38833 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCCCAAAATAAGGAGTTATCAGACAAGGTTTTGCGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTCCAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References