Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1408880..1409549 Replicon chromosome
Accession NZ_CP031242
Organism Haemophilus influenzae strain M21460

Toxin (Protein)


Gene name higB Uniprot ID A0A2R3G0F4
Locus tag DV390_RS07080 Protein ID WP_015701504.1
Coordinates 1408880..1409263 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A502K5Z3
Locus tag DV390_RS07085 Protein ID WP_005651224.1
Coordinates 1409247..1409549 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV390_RS07045 1405640..1405963 + 324 WP_038440695.1 DUF2190 family protein -
DV390_RS07050 1405944..1406255 + 312 WP_015701509.1 hypothetical protein -
DV390_RS07055 1406258..1406788 + 531 WP_042594859.1 phage tail protein -
DV390_RS07060 1406797..1407207 + 411 WP_042594861.1 phage tail protein -
DV390_RS07065 1407210..1407860 + 651 WP_038440702.1 hypothetical protein -
DV390_RS07070 1408135..1408542 + 408 WP_038440705.1 hypothetical protein -
DV390_RS07075 1408587..1408811 + 225 WP_038440708.1 DUF4035 domain-containing protein -
DV390_RS07080 1408880..1409263 + 384 WP_015701504.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DV390_RS07085 1409247..1409549 + 303 WP_005651224.1 XRE family transcriptional regulator Antitoxin
DV390_RS07090 1409565..1409801 + 237 WP_101494098.1 hypothetical protein -
DV390_RS07095 1409853..1413197 + 3345 WP_042594864.1 phage tail tape measure protein -
DV390_RS07100 1413206..1413538 + 333 WP_038440713.1 phage tail protein -
DV390_RS09370 1413866..1414024 + 159 WP_005651234.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1373245..1424539 51294


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-81)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14868.05 Da        Isoelectric Point: 4.4987

>T108703 WP_015701504.1 NZ_CP031242:1408880-1409263 [Haemophilus influenzae]
MKQEWEVILQDPLLNWLETLAEDDVLKIYAALELLSTEGPQLSRPYADTLQGSKYTNLKELRVQSKLSVFRLFYIFDPVR
QAIVLCGGDKKGKKEKLFYKEMIALAEQTYDDYLSELTKEQENEREI

Download         Length: 384 bp

>T108703 NZ_CP031242:1408880-1409263 [Haemophilus influenzae]
ATGAAACAAGAATGGGAAGTAATTTTACAAGACCCACTTTTGAACTGGTTAGAAACGCTGGCAGAAGATGACGTATTAAA
AATCTATGCGGCGTTGGAATTATTATCAACAGAAGGTCCACAATTAAGCAGACCTTATGCGGATACGCTGCAAGGCTCTA
AATATACCAATTTAAAAGAATTGCGAGTACAGTCTAAATTATCGGTATTCCGTTTATTTTATATTTTCGACCCTGTCAGA
CAAGCGATTGTTTTATGTGGCGGAGATAAAAAAGGCAAGAAAGAAAAACTCTTTTACAAAGAGATGATTGCCCTAGCGGA
ACAAACCTATGATGATTACCTTTCTGAATTAACTAAGGAGCAAGAAAATGAGCGTGAAATTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11258.21 Da        Isoelectric Point: 9.5655

>AT108703 WP_005651224.1 NZ_CP031242:1409247-1409549 [Haemophilus influenzae]
MSVKFKDLMNNLPAEKQAKVKAMADDMRMELQLYRIREELELSQKQMAEALSISQPSVVALEKRGNDIKLSSVKRYIEAM
GGVLNLSVELPTGKTVTFNL

Download         Length: 303 bp

>AT108703 NZ_CP031242:1409247-1409549 [Haemophilus influenzae]
ATGAGCGTGAAATTTAAAGATCTGATGAATAATCTTCCAGCTGAAAAGCAAGCGAAAGTGAAAGCTATGGCAGACGATAT
GCGAATGGAGTTACAACTTTACCGTATTCGTGAAGAATTAGAGCTTTCACAAAAGCAAATGGCAGAAGCATTAAGTATTT
CTCAGCCGTCAGTTGTCGCCCTTGAAAAACGTGGCAATGACATTAAATTATCATCAGTTAAACGTTACATTGAAGCAATG
GGTGGTGTGTTAAATTTATCGGTTGAATTACCCACAGGAAAAACAGTTACTTTCAACTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3G0F4

Antitoxin

Source ID Structure
AlphaFold DB A0A502K5Z3

References