Detailed information of TA system TA108696

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA-HipA
• Location: 1440802..1442150
• Replicon: chromosome
• Accession: NZ_CP031241
• Organism: Haemophilus influenzae strain M17648

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: DV384_RS07115
• Protein ID: WP_005694624.1
• Coordinates: 1440802..1441833 (-)
• Length: 344 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: A0A2S9RZQ1
• Locus tag: DV384_RS07120
• Protein ID: WP_005672747.1
• Coordinates: 1441830..1442150 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV384_RS07105	1437322..1439067	+	1746	WP_114934646.1	ABC transporter ATP-binding protein/permease	-
DV384_RS07110	1439060..1440718	+	1659	WP_114934647.1	thiol reductant ABC exporter subunit CydC	-
DV384_RS07115	1440802..1441833	-	1032	WP_005694624.1	type II toxin-antitoxin system HipA family toxin	Toxin
DV384_RS07120	1441830..1442150	-	321	WP_005672747.1	type II toxin-antitoxin system HipA family toxin	Antitoxin
DV384_RS07125	1442138..1442446	-	309	WP_005650822.1	helix-turn-helix domain-containing protein	-
DV384_RS07130	1442646..1443647	-	1002	WP_005690169.1	class II fructose-bisphosphatase	-
DV384_RS07135	1443809..1444027	+	219	WP_005650820.1	cell division protein ZapB	-
DV384_RS07140	1444124..1444564	+	441	WP_114934648.1	FMN-binding protein MioC	-
DV384_RS07145	1444561..1444995	+	435	WP_006995247.1	D-tyrosyl-tRNA(Tyr) deacylase	-
DV384_RS07150	1445301..1445777	-	477	WP_005661209.1	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	-
DV384_RS07155	1445774..1446451	-	678	WP_114934649.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-
DV384_RS07160	1446451..1446729	-	279	WP_005661211.1	cell division protein FtsB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (56-290)

Antitoxin

• HipA, N-terminal subdomain 1 (9-101)

Sequences

Toxin

Protein

• Length: 344 a.a.
• Molecular weight: 39832.46 Da
• Isoelectric Point: 6.4335

>T108696 WP_005694624.1 NZ_CP031241:c1441833-1440802 [Haemophilus influenzae]
MNFCRILLKPLKKNEALSGYSAEGLHYLTDNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDEHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVITRFDRDKQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEIIQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNLLNEPEL

Nucleotide

• Length: 1032 bp

>T108696 NZ_CP031241:c1441833-1440802 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTGAAGAAAAATGAAGCACTTTCAGGTTACAGTGCTGAAGGTTTGCATTA
CCTTACAGACAATAAACATTTTAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAGCCAAAATTACAGCTTATTATCAAAGATGAGCACTTTGACAGCGTAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACACGCCACCATGCGCATTATGAA
AGAATTAGGGTTTGATGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAAGAATTTGCTTTTGTTA
TAACGCGTTTTGATCGTGATAAACAGCAAAAACCAATGCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TATGGAAAAATAGGTGCAGATAATGAGCAATATGTAAGTTATGAACAAATTGCTAAGTTTATTTTGCAGCACACAGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGATTTTGTGTCAGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCTTTGCCATTGTTAGCGCGAGAAGAAGGTAATGCCACACTAGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTATACAAGAAAAGGAAAAAGTAGAGCAGATTTATTCACAATCCTTTATGCCGCAGCCACAT
ATTGATTGCGTGCTGAAAACTTATCGCAAGCGTTTAGCTTTGCTTAACCTATTAAATGAACCTGAACTATAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12453.12 Da
• Isoelectric Point: 5.9670

>AT108696 WP_005672747.1 NZ_CP031241:c1442150-1441830 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
ESDMFRFLLNNGENMLGAVQIQEEKQ

Nucleotide

• Length: 321 bp

>AT108696 NZ_CP031241:c1442150-1441830 [Haemophilus influenzae]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGCGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTTCTTACAACCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGTCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTCGTCCCAGAAGGCTGGCTAAAACACAAATATGCACTTCATCAACGAATTGAT
GAAAGCGATATGTTTCGCTTTTTACTTAATAACGGGGAAAATATGTTAGGCGCAGTGCAAATTCAGGAAGAAAAACAATG
A

Structures

Antitoxin

• AlphaFold DB: A0A2S9RZQ1