Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1890012..1890651 Replicon chromosome
Accession NZ_CP031240
Organism Haemophilus haemolyticus strain M19345

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DV427_RS09310 Protein ID WP_114892143.1
Coordinates 1890346..1890651 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DV427_RS09305 Protein ID WP_114892142.1
Coordinates 1890012..1890335 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV427_RS09425 1885755..1885928 - 174 WP_005637028.1 DUF5363 domain-containing protein -
DV427_RS09290 1885925..1887769 - 1845 WP_114892139.1 tRNA(Met) cytidine acetyltransferase TmcA -
DV427_RS09295 1887774..1888115 - 342 WP_114892140.1 SirB2 family protein -
DV427_RS09300 1888177..1889847 - 1671 WP_114892141.1 energy-dependent translational throttle protein EttA -
DV427_RS09305 1890012..1890335 - 324 WP_114892142.1 HigA family addiction module antidote protein Antitoxin
DV427_RS09310 1890346..1890651 - 306 WP_114892143.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DV427_RS09315 1890977..1891597 + 621 WP_114892144.1 zinc transporter binding subunit ZevA -
DV427_RS09320 1891600..1892574 + 975 WP_114892145.1 zinc transporter permease subunit ZevB -
DV427_RS09325 1892691..1893146 + 456 Protein_1767 IS3 family transposase -
DV427_RS09330 1893190..1893624 - 435 Protein_1768 DUF2827 family protein -
DV427_RS09335 1893754..1894995 - 1242 WP_114892146.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12209.84 Da        Isoelectric Point: 9.1259

>T108693 WP_114892143.1 NZ_CP031240:c1890651-1890346 [Haemophilus haemolyticus]
MFNLKREHFRDDYLYRFYQYGNTHSKIPSNLSKVLARKLDMISAAEDINDLRSPPANHLELLEPKENKIYSIRVNKQYRL
IFKYENNEVNNLYLDPHSYNL

Download         Length: 306 bp

>T108693 NZ_CP031240:c1890651-1890346 [Haemophilus haemolyticus]
ATGTTTAATTTAAAGCGTGAGCATTTTAGAGATGATTATCTTTATAGGTTTTATCAATATGGTAATACTCATAGTAAGAT
TCCTTCTAATTTATCTAAAGTATTGGCAAGAAAATTGGATATGATAAGTGCTGCGGAAGATATCAATGATTTACGTTCTC
CGCCGGCTAATCACTTAGAGTTGCTTGAGCCAAAAGAAAATAAAATTTATTCCATTCGAGTAAATAAACAATATCGCCTA
ATTTTTAAATATGAGAATAATGAAGTAAATAATTTATATTTAGATCCACATTCTTATAATTTATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12288.11 Da        Isoelectric Point: 7.4049

>AT108693 WP_114892142.1 NZ_CP031240:c1890335-1890012 [Haemophilus haemolyticus]
MMTRKPTSVGEILQEEFLEPLSLKINDLAQILDVHRNTASNIVNNSSRITLEMAVKLAKAFDTTPEFWLNLQTRIDLWDL
EHNKRFQQSLANVKPALHRHGTSTFAM

Download         Length: 324 bp

>AT108693 NZ_CP031240:c1890335-1890012 [Haemophilus haemolyticus]
ATGATGACGAGAAAACCCACCTCTGTTGGAGAAATTCTGCAAGAAGAGTTTTTAGAACCTTTAAGTCTTAAAATTAATGA
TTTAGCTCAAATTTTAGATGTACATCGTAATACGGCAAGTAATATCGTTAATAATAGTTCACGAATTACGCTAGAAATGG
CAGTTAAACTTGCTAAAGCATTTGATACCACGCCTGAGTTTTGGCTTAATCTGCAAACACGTATTGATTTATGGGACCTT
GAACACAATAAACGTTTTCAACAAAGTCTTGCAAATGTTAAGCCCGCTCTACATCGGCATGGTACTTCTACATTTGCAAT
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References