Detailed information of TA system TA108691

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA-HipA
• Location: 763250..764598
• Replicon: chromosome
• Accession: NZ_CP031240
• Organism: Haemophilus haemolyticus strain M19345

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: DV427_RS03770
• Protein ID: WP_114891352.1
• Coordinates: 763250..764281 (-)
• Length: 344 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: F9GV76
• Locus tag: DV427_RS03775
• Protein ID: WP_005635266.1
• Coordinates: 764278..764598 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV427_RS03760	759769..761514	+	1746	WP_114891350.1	ABC transporter ATP-binding protein/permease	-
DV427_RS03765	761507..763165	+	1659	WP_114891351.1	thiol reductant ABC exporter subunit CydC	-
DV427_RS03770	763250..764281	-	1032	WP_114891352.1	type II toxin-antitoxin system HipA family toxin	Toxin
DV427_RS03775	764278..764598	-	321	WP_005635266.1	type II toxin-antitoxin system HipA family toxin	Antitoxin
DV427_RS03780	764586..764894	-	309	WP_114891353.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (56-290)

Antitoxin

• HipA, N-terminal subdomain 1 (9-101)

Sequences

Toxin

Protein

• Length: 344 a.a.
• Molecular weight: 39739.23 Da
• Isoelectric Point: 5.6440

>T108691 WP_114891352.1 NZ_CP031240:c764281-763250 [Haemophilus haemolyticus]
MSFCRILLKPLKKNEALSGYSTEGLHYLTGNKNFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIINDDHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEENQKEFAFVIKRFDRDEQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGYATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKNYLKRLALLNVLNEPEL

Nucleotide

• Length: 1032 bp

>T108691 NZ_CP031240:c764281-763250 [Haemophilus haemolyticus]
ATGAGTTTTTGTCGTATTTTATTAAAGCCATTGAAGAAAAATGAAGCACTTTCAGGTTACAGCACTGAAGGTTTGCATTA
CCTTACAGGCAATAAAAATTTCAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCAATGATGATCACTTTGACAGCGTAAATCAACAA
GGAAATTATATTTTAAAGCCTTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACATGCCACCATGCGCATTATGAA
AGAATTAGGGTTTGATGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGTGAAGAAAATCAGAAAGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAGCAAAAACCAATGCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TATGGAAAAATAGGTGCTGATAATGAGCAATATGTGAGTTATGAACAAATTGCTAAGTTTATTTTGCAGCACACTGAAAA
TCATTTAGCTCAACAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTGGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGATTTTGTGTCGGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCCTTGCCATTGTTAGCGAGAGAAGAGGGGTATGCCACACTCGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTACACAAGAAAAGGAAAAGGTGGAGCAGATTTATTCACAATCGTTTATGCCGCAGCCACAT
ATTGATTGCGTACTGAAAAATTATCTTAAGCGTTTAGCGTTACTTAACGTATTAAATGAACCTGAGCTATAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12441.11 Da
• Isoelectric Point: 5.9670

>AT108691 WP_005635266.1 NZ_CP031240:c764598-764278 [Haemophilus haemolyticus]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFAYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYAFHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Nucleotide

• Length: 321 bp

>AT108691 NZ_CP031240:c764598-764278 [Haemophilus haemolyticus]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGTGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTGCTTACAATCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGCCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTCGTCCCAGAAGGCTGGCTAAAACACAAATATGCATTTCATCAACGAATTGAT
GAAGGTGATATGTTTCGCTTTTTACTTAATAATGGAGAAAATATGTTAGGCGCAGTGCAAATTCAGGAGGAGAAACAATG
A

Structures

Antitoxin

• AlphaFold DB: F9GV76