Detailed information of TA system TA108681

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA-HipA
• Location: 1701559..1702907
• Replicon: chromosome
• Accession: NZ_CP031237
• Organism: Haemophilus influenzae strain M12125

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: DV365_RS08365
• Protein ID: WP_005650824.1
• Coordinates: 1701876..1702907 (+)
• Length: 344 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: A0A2S9R6P7
• Locus tag: DV365_RS08360
• Protein ID: WP_005650823.1
• Coordinates: 1701559..1701879 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV365_RS08320	1696979..1697257	+	279	WP_005665661.1	cell division protein FtsB	-
DV365_RS08325	1697257..1697934	+	678	WP_014551114.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-
DV365_RS08330	1697931..1698407	+	477	WP_112081429.1	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	-
DV365_RS08335	1698717..1699151	-	435	WP_005687917.1	D-tyrosyl-tRNA(Tyr) deacylase	-
DV365_RS08340	1699148..1699588	-	441	WP_005687918.1	FMN-binding protein MioC	-
DV365_RS08345	1699682..1699900	-	219	WP_005650820.1	cell division protein ZapB	-
DV365_RS08350	1700062..1701063	+	1002	WP_042601475.1	class II fructose-bisphosphatase	-
DV365_RS08355	1701263..1701571	+	309	WP_005661200.1	helix-turn-helix domain-containing protein	-
DV365_RS08360	1701559..1701879	+	321	WP_005650823.1	type II toxin-antitoxin system HipA family toxin	Antitoxin
DV365_RS08365	1701876..1702907	+	1032	WP_005650824.1	type II toxin-antitoxin system HipA family toxin	Toxin
DV365_RS08370	1702991..1704649	-	1659	WP_114890679.1	thiol reductant ABC exporter subunit CydC	-
DV365_RS08375	1704642..1706387	-	1746	WP_114890680.1	ABC transporter ATP-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (56-290)

Antitoxin

• HipA, N-terminal subdomain 1 (9-101)

Sequences

Toxin

Protein

• Length: 344 a.a.
• Molecular weight: 39856.42 Da
• Isoelectric Point: 6.5054

>T108681 WP_005650824.1 NZ_CP031237:1701876-1702907 [Haemophilus influenzae]
MNFCRILLKPLKKNEVHSGYSTKGLHYLTGNKNFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDEHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQTEIHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEIIQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNVLHEPEL

Nucleotide

• Length: 1032 bp

>T108681 NZ_CP031237:1701876-1702907 [Haemophilus influenzae]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTAAAGAAAAATGAAGTTCATTCTGGTTACAGTACAAAAGGTTTACATTA
TCTTACAGGCAATAAAAATTTTAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCAAAGATGAGCACTTTGACAGCGTAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACATGCCACCATGCGCATTATGAA
AGAATTAGGGTTTGACGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAACAAACAGAGATTCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TATGGAAAAATAGGTGCAGATAATGAGCAATATGTGAGTTATGAACAAATTGCTAAGTTTATTTTGCAGCACACTGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGACTTTGTGTCAGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCCTTGCCATTGTTAGCGCGAGAAGAAGGTAATGCCACACTAGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTATACAAGAAAAGGAAAAAGTAGAGCAGATTTATTCACAATCCTTTATGCCGCAGCCACAT
ATTGATTGCGTGCTGAAAACTTATCGCAAGCGTTTAGCATTACTTAACGTATTACATGAACCTGAACTATAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12404.04 Da
• Isoelectric Point: 5.8850

>AT108681 WP_005650823.1 NZ_CP031237:1701559-1701879 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHHGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Nucleotide

• Length: 321 bp

>AT108681 NZ_CP031237:1701559-1701879 [Haemophilus influenzae]
ATGCGCGATTTAGTTCGCTCGGGAAAAGTATTTCTCTACGGTGAATTTATTGGCTTACTTAGAGAAGATCATCATGGTTT
TCATTTTTCTTACAACCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGTCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCCCTCGTACCCGAAGGCTGGCTAAAACACAAATATGCACTTCATCAACGAATTGAT
GAAGGTGATATGTTTCGCTTTTTACTTAATAATGGTGAAAATATGTTAGGCGCAGTGCAAATTCAGGAGGAAAAACAATG
A

Structures

Antitoxin

• AlphaFold DB: A0A2S9R6P7