Detailed information of TA system TA108620

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 3776842..3777064
• Replicon: chromosome
• Accession: NZ_CP031215
• Organism: Escherichia coli strain Es_ST80_L1_NDM_10_2017

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: DV870_RS19405
• Protein ID: WP_001295224.1
• Coordinates: 3776957..3777064 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3776842..3776900 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV870_RS19375	3772283..3773185	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
DV870_RS19380	3773196..3774179	+	984	WP_021531678.1	dipeptide ABC transporter ATP-binding protein	-
DV870_RS19385	3774176..3775180	+	1005	WP_000103570.1	dipeptide ABC transporter ATP-binding subunit DppF	-
DV870_RS19390	3775210..3776481	-	1272	WP_014640225.1	amino acid permease	-
-	3776842..3776900	-	59	-	-	Antitoxin
DV870_RS19405	3776957..3777064	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
DV870_RS19410	3777151..3778830	-	1680	WP_000191567.1	cellulose biosynthesis protein BcsG	-
DV870_RS19415	3778827..3779018	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
DV870_RS19420	3779015..3780586	-	1572	WP_074042579.1	cellulose biosynthesis protein BcsE	-
DV870_RS19425	3780859..3781047	+	189	WP_001063314.1	YhjR family protein	-
DV870_RS19430	3781059..3781811	+	753	WP_000279525.1	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T108620 WP_001295224.1 NZ_CP031215:3776957-3777064 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T108620 NZ_CP031215:3776957-3777064 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT108620 NZ_CP031215:c3776900-3776842 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin