Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2981559..2982151 Replicon chromosome
Accession NZ_CP031145
Organism Intrasporangium calvum strain C5

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag DN585_RS13725 Protein ID WP_114610380.1
Coordinates 2981870..2982151 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DN585_RS13720 Protein ID WP_114610379.1
Coordinates 2981559..2981852 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DN585_RS13690 2976713..2977720 - 1008 WP_114610374.1 DUF4037 domain-containing protein -
DN585_RS13695 2978061..2978336 + 276 WP_114610375.1 hypothetical protein -
DN585_RS13700 2978437..2979042 + 606 WP_013493703.1 phosphatase PAP2 family protein -
DN585_RS13705 2979047..2979577 + 531 WP_199921532.1 DUF2127 domain-containing protein -
DN585_RS13710 2979619..2980593 - 975 WP_169312924.1 ATP-binding protein -
DN585_RS18955 2981055..2981222 + 168 WP_199921533.1 hypothetical protein -
DN585_RS13720 2981559..2981852 - 294 WP_114610379.1 HigA family addiction module antidote protein Antitoxin
DN585_RS13725 2981870..2982151 - 282 WP_114610380.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DN585_RS13730 2983039..2983596 + 558 WP_114610381.1 hypothetical protein -
DN585_RS13735 2983596..2984447 + 852 WP_114610382.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
DN585_RS13740 2985382..2985591 + 210 WP_114610383.1 hypothetical protein -
DN585_RS13745 2986017..2986865 - 849 WP_114610384.1 IS21-like element helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10870.37 Da        Isoelectric Point: 8.0203

>T108542 WP_114610380.1 NZ_CP031145:c2982151-2981870 [Intrasporangium calvum]
VIRSFSNTMTERLWSRERTKKLDPRIERTALRKLVLLDAAEALDDLRVPPGNRLEALRGDRDGQHSIRINQQWRICFTWT
PAGPEDVEIVDYP

Download         Length: 282 bp

>T108542 NZ_CP031145:c2982151-2981870 [Intrasporangium calvum]
GTGATCAGGTCGTTCTCGAACACCATGACTGAACGGCTGTGGTCACGAGAACGCACCAAGAAGCTCGACCCGCGGATCGA
GCGGACCGCACTACGCAAGCTCGTCCTGCTCGATGCGGCCGAGGCCCTCGACGATCTGCGGGTCCCACCCGGCAACCGGC
TCGAAGCCCTGCGCGGCGACCGGGACGGACAACACAGCATCCGAATCAACCAGCAGTGGCGGATCTGCTTCACCTGGACA
CCCGCAGGGCCCGAAGACGTCGAGATCGTCGACTATCCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11010.67 Da        Isoelectric Point: 6.7586

>AT108542 WP_114610379.1 NZ_CP031145:c2981852-2981559 [Intrasporangium calvum]
MATIPPIHPGEVLLEDFLTPLEVTQHHLAVSIGVPPRRINEIVHGKRRITADTALRLARFFGTTDRFWLNLQTRYDLEIE
KDHLGAALDQIHPLQSA

Download         Length: 294 bp

>AT108542 NZ_CP031145:c2981852-2981559 [Intrasporangium calvum]
ATGGCGACCATCCCGCCCATCCACCCGGGGGAGGTCCTCCTCGAGGACTTCCTGACCCCGCTGGAGGTCACCCAGCACCA
CCTCGCCGTCTCGATCGGTGTCCCGCCGCGACGGATCAACGAGATCGTCCACGGCAAGCGACGGATCACCGCCGACACGG
CGCTTCGCCTGGCCCGCTTCTTCGGCACCACCGACCGGTTCTGGCTCAACCTGCAAACCCGTTACGACCTCGAGATCGAG
AAGGACCACCTCGGCGCCGCCCTCGACCAGATCCATCCCCTGCAGAGCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References