Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 745626..746142 Replicon chromosome
Accession NZ_CP031145
Organism Intrasporangium calvum strain C5

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag DN585_RS03460 Protein ID WP_114609441.1
Coordinates 745626..745883 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag DN585_RS03465 Protein ID WP_114609442.1
Coordinates 745885..746142 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DN585_RS03435 740874..741842 + 969 WP_114609436.1 MBL fold metallo-hydrolase -
DN585_RS03440 741861..743603 + 1743 WP_114609437.1 CocE/NonD family hydrolase -
DN585_RS03445 743600..743965 + 366 WP_114609438.1 acetyl-CoA acetyltransferase -
DN585_RS03450 743962..744657 + 696 WP_114609439.1 3-oxoacid CoA-transferase subunit A -
DN585_RS03455 744657..745289 + 633 WP_114609440.1 3-oxoacid CoA-transferase subunit B -
DN585_RS03460 745626..745883 - 258 WP_114609441.1 Txe/YoeB family addiction module toxin Toxin
DN585_RS03465 745885..746142 - 258 WP_114609442.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
DN585_RS03475 746631..746948 + 318 WP_114609443.1 hypothetical protein -
DN585_RS03480 747171..747929 + 759 WP_013491707.1 aquaporin family protein -
DN585_RS03485 748002..749216 + 1215 WP_013491708.1 formaldehyde dehydrogenase, glutathione-independent -
DN585_RS03490 750085..750675 + 591 WP_013491711.1 nucleotidyltransferase domain-containing protein -
DN585_RS03495 750675..751076 + 402 WP_114609444.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10144.43 Da        Isoelectric Point: 6.2185

>T108539 WP_114609441.1 NZ_CP031145:c745883-745626 [Intrasporangium calvum]
VLLVWDENAWEDYLWWQAQDRRVLKRINVLLADIQRNGNEGIGKPEALKHDFAGYWSRRITDEHRLVYKVVDDEVRIAAC
SYHYG

Download         Length: 258 bp

>T108539 NZ_CP031145:c745883-745626 [Intrasporangium calvum]
GTGCTGCTCGTCTGGGACGAGAACGCGTGGGAGGACTATCTCTGGTGGCAAGCGCAAGACCGCAGGGTCCTGAAGAGGAT
CAACGTGCTGCTCGCTGACATCCAACGCAACGGCAACGAGGGCATCGGCAAGCCGGAAGCGCTCAAGCATGACTTCGCGG
GCTACTGGTCCAGACGCATCACCGATGAGCACCGCCTCGTGTACAAAGTCGTCGACGACGAGGTCAGGATCGCTGCCTGT
AGCTACCACTACGGATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9648.84 Da        Isoelectric Point: 4.7119

>AT108539 WP_114609442.1 NZ_CP031145:c746142-745885 [Intrasporangium calvum]
MKTMSYTESRARYAEVLDGVANDREEVVITRAGHEPVVIVSLEDYESLRETAWLMRSPANARRLLDAMERLEAGRGKGHD
LIETD

Download         Length: 258 bp

>AT108539 NZ_CP031145:c746142-745885 [Intrasporangium calvum]
ATGAAGACGATGAGTTACACCGAATCCCGGGCTCGCTACGCCGAGGTACTCGACGGGGTTGCCAACGACCGTGAGGAGGT
CGTCATCACCCGGGCGGGACATGAGCCCGTAGTCATCGTCTCGCTCGAGGACTACGAGTCCCTCCGGGAGACGGCCTGGC
TGATGCGTTCACCCGCCAACGCCCGACGCCTCCTCGACGCCATGGAGCGTCTGGAGGCCGGCCGCGGAAAAGGTCATGAC
CTGATCGAGACCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References