Detailed information of TA system TA108530

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2469375..2469559
• Replicon: chromosome
• Accession: NZ_CP031131
• Organism: Staphylococcus aureus strain E16SA093

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: DU470_RS12885
• Protein ID: WP_000482650.1
• Coordinates: 2469452..2469559 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2469375..2469435 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DU470_RS12860	2464885..2465052	-	168	WP_001792506.1	hypothetical protein	-
DU470_RS12870	2465283..2467016	-	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
DU470_RS12875	2467041..2468804	-	1764	WP_001064820.1	ABC transporter ATP-binding protein/permease	-
-	2469375..2469435	+	61	-	-	Antitoxin
DU470_RS12885	2469452..2469559	-	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
DU470_RS12890	2469693..2470079	-	387	WP_000779358.1	flippase GtxA	-
DU470_RS12895	2470337..2471479	+	1143	WP_001176863.1	glycerate kinase	-
DU470_RS12900	2471539..2472198	+	660	WP_000831298.1	membrane protein	-
DU470_RS12905	2472380..2473591	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
DU470_RS12910	2473714..2474187	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T108530 WP_000482650.1 NZ_CP031131:c2469559-2469452 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T108530 NZ_CP031131:c2469559-2469452 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT108530 NZ_CP031131:2469375-2469435 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin