Detailed information of TA system TA108522

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2013480..2013787
• Replicon: chromosome
• Accession: NZ_CP031131
• Organism: Staphylococcus aureus strain E16SA093

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: DU470_RS10350
• Protein ID: WP_011447039.1
• Coordinates: 2013611..2013787 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2013480..2013619 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DU470_RS10305	2008830..2009090	+	261	WP_001791826.1	hypothetical protein	-
DU470_RS10310	2009143..2009483	-	341	Protein_1899	complement inhibitor SCIN-A	-
DU470_RS10315	2010167..2010616	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
DU470_RS10320	2010711..2011046	-	336	Protein_1901	SH3 domain-containing protein	-
DU470_RS10330	2011696..2012187	-	492	WP_000919350.1	staphylokinase	-
DU470_RS10335	2012378..2013133	-	756	WP_000861038.1	CHAP domain-containing protein	-
DU470_RS10340	2013145..2013399	-	255	WP_000611512.1	phage holin	-
DU470_RS10345	2013451..2013558	+	108	WP_001791821.1	hypothetical protein	-
-	2013480..2013619	+	140	NuclAT_0	-	Antitoxin
-	2013480..2013619	+	140	NuclAT_0	-	Antitoxin
-	2013480..2013619	+	140	NuclAT_0	-	Antitoxin
-	2013480..2013619	+	140	NuclAT_0	-	Antitoxin
DU470_RS10350	2013611..2013787	-	177	WP_011447039.1	putative holin-like toxin	Toxin
DU470_RS10355	2013937..2014233	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
DU470_RS10360	2014291..2014578	-	288	WP_001040261.1	hypothetical protein	-
DU470_RS10365	2014625..2014777	-	153	WP_001153681.1	hypothetical protein	-
DU470_RS10370	2014767..2018552	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / scn / chp / sak / hlb / groEL	2009143..2061352	52209

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T108522 WP_011447039.1 NZ_CP031131:c2013787-2013611 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T108522 NZ_CP031131:c2013787-2013611 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT108522 NZ_CP031131:2013480-2013619 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin